脂肪干细胞在促进移植皮瓣血管化中的研究进展  

Research progress of the vascularization of the skin flap with adipose-derived stem cells

作　　者：张园园[1] 刘真 贾赤宇 

机构地区：[1]山西医科大学,太原030001 [2]解放军第三〇九医院烧伤整形科,北京100091

出　　处：《中华损伤与修复杂志（电子版）》2015年第5期66-69,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家自然科学基金面上项目(81372051);总参军事医学和老年病科研基金项目(ZCWS14B06);解放军第三〇九医院院管课题(2014MS-001);全军医学科技"十二五"重点课题(BWS11C061);国家重点基础研究发展计划(973计划)(2012CB518104)

摘　　要：皮瓣移植是整形外科中应用最广、修复皮肤缺损最为有效的方法,早期建立良好的血运是移植皮瓣成活的关键。随着干细胞研究的不断深入,发现脂肪干细胞(ADSC)在促血管化中的作用较为确切,且ADSC具有来源充足、提取方便、低免疫原性、无伦理问题等优势,结合ADSC来促进移植皮瓣血管化的作用逐渐得到实验证实,其主要通过两种作用机制促进移植皮瓣血管新生,为移植皮瓣提供良好血运。总之,这些实验研究为将来ADSC应用于临床奠定了基础,ADSC有望为皮瓣移植术后预防缺血坏死提供一条新途径。Flap transplantation is one of the most widely used and the most effective methods for repair of skin defect in plastic surgery. Early establishment of good circulation is the key method to the survival of the transplanted flap. With the deepening of stem cell research, a growing number of studies have shown that the role of adipose-derived stem cells are precise for the vascularization. In addition, adipose- derived stein cells have some special advantages such as abundant, easy extraction, low immunogenic, no ethical problems, et al. It is verified by experiments gradually that adipose-derived stem cells promot the skin flap vascularization. There are two important mechanisms promoting vasculogenesis and providing good vascularization for the tansplanted flap. In conclusion, These expriments lay a foundation for adipose-derived stern cells clinical applications in the future. Furthor more, adipose-derived stem cells may some day become one of effective methods to prevent flap ischemia and necrosis.

关 键 词：干细胞 外科皮瓣 新生血管化 生理性 移植 

分 类 号：R622.1[医药卫生—整形外科]