退行性心瓣膜合并房颤患者APN与NT-proBNP的变化  

The change of APN and NT-proBNP in degenerative heart valvular disease patients with atrial fibrillation

作　　者：林森[1] 周华兰[1] 胡得飞[1] 

机构地区：[1]徐州医学院附属淮安医院,江苏淮安223002

出　　处：《中国实验诊断学》2015年第12期2051-2053,共3页Chinese Journal of Laboratory Diagnosis

基　　金：江苏省淮安市科技支撑计划(社会发展)项目(编号:HAS2010034)

摘　　要：目的探讨退行性心瓣膜病(degenerative heart valvular disease,DHVD)合并房颤(atrial fibrillation AF)患者脂联素(adiponectin APN)、N末端B型利钠肽原(N-terminal pro-brain natriuretic peptide NT-proBNP)变化。方法选择60岁以上的DHVD患者210例,分为伴AF的DHVD组102例及不伴AF的DHVD组108例,健康者98例作为对照组,所有入选者NYHA心功能分级≤Ⅱ级。测定血清APN、NT-proBNP水平。比较各组间的差异,同时分析APN与NT-proBNP的相关性。结果 DHVD患者血清APN降低明显(P<0.01),尤其是伴AF的DHVD组降低更明显(P<0.01);不伴AF的DHVD组血清NT-proBNP与正常对照组差异不明显(P>0.05),而伴AF的DHVD组血清NT-proBNP水平明显高于不伴AF组(P<0.01)。伴AF的DHVD组血清APN与NT-proBN呈负相关(r=-0.605,P<0.01)。结论无心力衰竭的DHVD合并AF患者APN水平下降、NT-proBNP水平升高,APN与NT-proBNP呈负相关。Objective To investigate the variance of serum adiponectin（APN）and N-terminal pro-brain natriuretic peptide（NT-proBNP）in degenerative heart valvular disease（DHVD）patients with atrial fibrillation（AF）and the relationship between serum APN and NT-proBNP.Methods A case-control study was conducted in DHVD patients with AF（102）,without AF（108）and normal subjects（98）,and all had cardiac function of NYHA class ≤ Ⅱ.The serum APN,NT-proBNP were measured,associations were analyed among three groups.Results Serum APN levels significantly decreased（P〈0.01）in both patients with DHVD than that in normal control;APN levels in DHVD with AF group significantly decreased than in DHVD without AF（P〈0.01）.NT-proBNP levels were not different in DHVD patients without AF and controls（P〉0.05）.While DHVD patients with AF had significantly higher NT-proBNP levels than that without AF（P〈0.01）.Serum APN level was negativly associated with NT-proBNP in DHVD patients with AF（r=-0.605,P〈0.01）.Conclusion DHVD patients with AF but without obvious heart failure disclose low APN levels and high levels of NT-proBNP.

关 键 词：退行性心瓣膜病 脂联素 N末端B型利钠肽原 

分 类 号：R542.5[医药卫生—心血管疾病]