固-液相转移催化法合成共聚酸酐及其性能研究  

The Synthesis and Characterization of Copolyanhydride via Solid-Liquid Phase Transfer Catalysis

作　　者：李福全[1] 闫莉 

机构地区：[1]呼和浩特民族学院,呼和浩特010050 [2]华北理工大学材料科学与工程学院,唐山063009

出　　处：《高分子通报》2015年第11期50-55,共6页Polymer Bulletin

基　　金：内蒙古自治区高等学校科学研究项目(NJZY11245)

摘　　要：采用18-冠-6(18C6)为相转移催化剂,制备了一系列不同单体比例的聚[1,3-双(对羧基苯氧基)丙烷-癸二酸]共聚酸酐P(CPP-SA),并优化了聚合反应条件。P(CPP-SA)化学结构由傅里叶红外光谱(FT-IR)和核磁共振氢谱(1 H-NMR)表征,并通过特征黏度计算了P(CPP-SA)的黏均分子量。结果表明最佳的反应条件是18C6的用量20%,反应时间15h,P(CPP-SA)特征黏度可达到1.2dL/g,黏均分子量为2.02×105。将P(CPP-SA)置于pH=7.4的磷酸缓冲溶液中进行体外降解,结果表明,降解率与CPP/SA比例有关,其中P(CPP-SA)(CPP/SA=50/50mol/mol)的共聚酸酐降解率与降解时间接近线性关系,具有较好的应用前景。A series of poly [ 3-bis （p-carboxyphenoxy） propane-sebacic acid] copolymers （P （CPP-SA）） with different monomer proportions were synthesized via solid-liquid phase transfer catalytic method using 18-crown-6（18C6） as catalyst. The structures of P（CPP-SA）s were characterized by FT-IR and 1H-NMR methods. The viscosity-average molecular weights of P（CPP-SA）s were calculated though the intrinsic viscosities. The reaction conditions were investigated that using 20% 18C6 after 15h the intrinsic viscosity of P（CPP-SA） reached to 1.2dL/g with the viscosity-average molecular weight was 2.02×10^5. The in-vitro degradation tests of P（CPP-SA）s were carried out in phosphate buffer solution （pH= 7.4）. The results indicated that the degradation ratioes depended on the monomer proportions. When the CPP/SA was 50/ 50 （tool/tool）, the linear relationship between degradation ratio and degradation time was verified. The application of P （CPP-SA） （CPP/SA= 50/50） was well promising.

关 键 词：共聚酸酐 相转移 体外降解 

分 类 号：O632.5[理学—高分子化学]