基于正虚病机的益气健脾法治疗对HBV-ACLF患者外周血T淋巴细胞的影响  

Effects of Treatment on T Lymphocyte frequency with Principle of Strengthening Vital Qi and the Spleen Based on the Mechanism of Deficiency in Vital Qi in patients with HBV-ACLF

作　　者：廉亚男[1,2] 徐立华[1,2] 谭善忠[1,2] 肖倩[2] 孙薇薇[2] 沈建军[2] 梁重峰[2] 蒋淑莲[2] 

机构地区：[1]南京中医药大学,江苏南京210046 [2]江苏省南京市第二医院,江苏南京210003

出　　处：《中国中医急症》2015年第12期2106-2108,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：江苏省南京市医学科技发展项目(DYY056;ZKX13018);江苏省中医药领军人才培养项目(LJ200922);江苏省"333高层次人才培养工程"项目(苏人才〔2011〕15号)

摘　　要：目的观察基于正虚病机的益气健脾法治疗对乙肝病毒相关慢加急性肝衰竭(HBV-ACLF)患者外周血T淋巴细胞的影响。方法将60例HBV-ACLF患者按随机数字表法分为对照组与治疗组两组各30例。对照组予常规内科综合治疗,治疗组在内科综合治疗基础上加用以益气健脾为主的中药口服。两组疗程均为4周。结果治疗4周后治疗组总有效率为70.00%,明显优于对照组的43.33%(P<0.05);两组治疗后,治疗组中医证候评分、终末期肝病模型(MELD)评分、胆红素(TBIL)、凝血酶原活动度(PTA)改善程度均明显优于对照组(P<0.05);T淋巴细胞频数改善情况治疗组较对照组显著(P<0.05)。结论在内科综合治疗基础上,基于正虚病机以益气健脾法治疗HBV-ACLF更有利于改善肝脏功能,提高有效率,其药理机理可能与改善其"耗损"的T淋巴细胞功能相关。Objective： To observe the effects of treatment on T lymphocyte frequency by principle of strengthen- ing vital Qi and the spleen based on the mechanism of deficiency in vital Qi in patients with hepatitis B virus re- lated with acute-on chronic liver failure （HBV-ACLF）. Methods： 60 patients with HBV-ACLF were randomly divided into the control group and the treatment group,30 cases in each. The control group were given the con- ventional internal medicine therapy ,and the treatment group were given the internal medicine therapy with oral decoction of strengthening vital Qi and the spleen based on the mechanism of deficiency in vital Qi. The treatment course was 4 weeks. Results： After treatment,the effective rate （70.0%） in the treatment group was better than that （43.33%） in the control group （P〈0.05）. TCM symptom score,MELD score,TBil and PTA in the treatment group was improved better than those of the control group,including T lymphocyte frequency, and the difference was statistically significant （P 〈 0.05）. Conclusion： The treatment on T lymphocyte fi＇equency by principle of strengthening vital Qi and the spleen based on the mechanism of deficiency in vital Qi in patients with HBV-A- CLF is more advantageous to improve liver function and the effective rate. Its pharmacological mechanism may be related with improving patients＂ so- called T lymphocyte function exhausted.

关 键 词：乙肝病毒相关慢加急性肝衰竭 正虚病机 益气健脾法 T淋巴细胞 

分 类 号：R575.3[医药卫生—消化系统]