MMP9及炎性因子TNF-α、IL-4在小儿变异性哮喘中的诊断价值  

Diagnostic Value of MMP9 and Inflammatory Factor of TNF–α and IL-4 in Pediatric Variant Asthma

作　　者：林俊荣[1] 刘日阳[1] 

机构地区：[1]惠州市中心人民医院儿科,广东惠州516000

出　　处：《辽宁医学院学报》2015年第6期50-52,共3页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的探讨MMP9及炎性因子TNF-α、IL-4在小儿变异性哮喘中的诊断意义。方法随机选取咳嗽变异性哮喘患儿50例,感染性咳嗽患儿50例及同期健康儿童50例为对照组,采用Elias法检测3组讨MMP9及炎性因子TNF-α、IL-4水平。结果变异性哮喘患儿血清MMP9水平为(144.15±35.37)ng/L,炎性因子TNF-α、IL-4水平分别为(0.75±0.13)ng/L和(90.88±15.86)ng/m L,均显著高于感染性咳嗽组及正常对照组(P均<0.01),且上述指标在感染性咳嗽组中亦明显高于对照组,差异有统计学意义(P<0.01);咳嗽变异性哮喘发作时间大于15 d组患儿血清MMP9及炎性因子TNF-α、IL-4水平均显著高于咳嗽时间小于15 d组,差异具有统计学意义(P均<0.01),直线相关分析显示MMP9、TNF-α和IL-4均与咳嗽持续时间呈正相关(r分别为0.68、0.44、0.78,P<0.05)。结论检测患儿血清MMP9及炎性因子TNF-α、IL-4可以反应气道炎症状态,且有助于鉴别诊断变异性哮喘与感染性咳嗽及判断病情,具有显著的临床意义。Objective To study the diagnostic value of MMP9 and inflammatory factor of TNF -α, IL - 4 in pediatric variant asthma. Methods 50 cases of children with cough variant asthma were randomly selected, while 50 cases of children with infectious cough and 50 cases of healthy children were randomly selected as control group. Elias method is used to detect the levels of MMP9 and inflammatory factor TNF - α, IL -4 in three groups. Results The levels of serum MMP9 were （ 144. 15 ± 35.37 ） ng/L in variant asthma children, and the inflammatory factor levels of TNF - α, IL -4 were （0. 75 ±0. 13） ng/L and （90. 88 ± 15.86） ng/mL re- spectively. All of them were significantly higher than infectious cough group and normal control group （P 〈 0. 01 ）. The asthma attack time of children with cough variant lasted for more than 15 days had significantly higher levels of MMP9 and inflammatory factor, TNF - α and IL -4, than those of children with asthma attack time lasting less than 15 days （P 〈0. 01 ）. The linear correlation analysis showed that MMP9, TNF - α and IL -4 were positively correlated with the duration of cough （r： 0. 68, 0. 44, and 0. 78 respectively, P 〈 0. 05 ）. Conclusion The serum MMP9 and inflammatory factor, TNF -α and IL - 4, can reflect the state of airway inflam- mation, and is helpful to diagnosis and condition judgment. It is of great clinical significance.

关 键 词：MMP9 TNF-Α IL-4 变异性哮喘 

分 类 号：R725.6[医药卫生—儿科]