基于共轭聚合物的核酸生物传感器的应用  

The Application of DNA Biosensor Based on Conjugated Polymers

作　　者：马昀[1] 周妍[1] 杜文琦[1] 缪智辉[1] 祁争健[1] 

机构地区：[1]东南大学化学化工学院,南京211189

出　　处：《化学进展》2015年第12期1799-1807,共9页Progress in Chemistry

基　　金：江苏省科技成果转化专项基金(No.BA2014123);国家重大科学仪器设备开发专项(No.2014YQ060773)资助~~

摘　　要：共轭聚合物的π电子体系及共轭离域结构,使其具有良好的发光性能。聚合物链可充当"分子导线",能够成倍放大光学信号,从而有效提高检测灵敏度。而核酸适体(aptamer)在特异性、与靶物质亲合力、信号传导方面比其他识别元件具有更大的优势,因此共轭聚合物的核酸生物传感器在生物检测方面得到了迅速发展。本文主要总结了近年来共轭聚合物的核酸生物传感器在生物检测方面的应用,并进一步对该类型传感器的发展趋势作出了展望。Conjugated polymers,with π electron systems and highly delocalized conjugated structures,exhibit excellent luminescence properties. The polymer chains can work as molecular wire,which will lead to the amplification of optical signals and thus improve the detecting sensitivity. Aptamer has advantages in specificity,affinity with targets and signal transmission,hence,nucleic acid biosensors based on conjugated polymers have witnessed a rapid development in bio-detection. The applications of nucleic acid biosensors based on conjugated polymers in recent years are summarized. Finally,an outlook of the developing trend for these sensors is given.

关 键 词：共轭聚合物 核酸适体 生物检测 荧光共振能量转移 构象变化 

分 类 号：O621.3[理学—有机化学] O631.24[理学—化学]