透骨消痛颗粒干预早中期兔骨关节炎的影像学观察  

Imaging study on osteoarthritis in rabbits treated with Tougu Xiaotong Granule

作　　者：许亚晔[1] 卢小冬[2] 郑章和[1] 陈文列[2,3,4] 林如辉[2,3,4] 戚婉[1] 叶秀芳[1] 吴广文[2,3,4] 吴追乐[2,3,4] 刘献祥[2,3,4] 

机构地区：[1]福建中医药大学附属人民医院影像科,福建福州350004 [2]福建中医药大学中西医结合研究院,福州350122 [3]国家中医药三级科研实验室-中药药理(细胞结构与功能)实验室,福建福州350122 [4]福建省中西医结合老年性疾病重点实验室,福建福州350122

出　　处：《中国中西医结合影像学杂志》2015年第6期593-597,共5页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：福建省自然科学基金项目(2014J01356);陈可冀中西医结合发展基金项目(CKJ2011004)

摘　　要：目的 :应用影像学方法 ,观察透骨消痛颗粒对早中期兔骨关节炎(osteoarthritis,OA)模型的干预作用,探讨影像学技术在OA实验研究中的应用价值。方法:新西兰大白兔48只,采用改良Hulth法造模,动物分成正常组、OA模型组、透骨消痛颗粒低、中、高剂量组和壮骨关节丸组,术后4、8、12、16周进行影像学检查(DR、CT、MRI),观察关节间隙狭窄、软骨下骨质变化、骨赘、关节积液、关节软骨等改变。结果:OA模型组各时段关节腔积液都较多,实验前期(4、8周)见软骨面毛糙,软骨下骨轻度增生硬化,实验后期(12、16周)软骨凸凹不平,软骨下骨增生硬化范围增大,内侧关节间隙略狭窄;透骨消痛颗粒中、高剂量组各时段,关节腔积液都较模型组少,后期见软骨面毛糙、软骨下骨硬化,且高剂量组病变程度最轻。结论:透骨消痛颗粒能减轻OA关节及滑膜炎症,延缓软骨损伤,延迟软骨下骨病变。MRI能较全面地观察膝OA,对早期病变更敏感、更准确。Object：To investigate the effection of Tougu Xiaotong Granules in early and mid osteoarthritis of rabbits and the application value of imaging technology in OA experiment. Methods：48 New Zealand white rabbits were randomly divided into normal group,model group,Tougu Xiaotong group,and bolus group. All models were based on the improved Hulth. DR,CT,MRI screening technology was taken in 4W,8W,12W,16W after operation,observing the changes of joint space narrowing,subchondral bone,osteophytes,arthroedema,cartilage,et al. Results：Model group had more arthroedema each time,early experiments （4 and 8 weeks） could observe subchondral sclerosis,late experiments （12 and 16 weeks） slightly joint space narrowing could be seen. Tougu Xiaotong group of mid-dose and high-dose had lesser arthroedema than model group each time,with cartilage surface coarse and subchondral sclerosis and lightest high-dose group lesions in late experiments. The performance of bolus group was between high-and low-dose Tougu Xiaotong group. Conclusion：Tougu Xiaotong Granules can reduce inflammation of OA,delay lesion of subchondral bone and recover the cartilage.

关 键 词：骨关节炎 透骨消痛颗粒 磁共振成像 放射摄影术 

分 类 号：R285.5[医药卫生—中药学] R445.2[医药卫生—中医学]