IgG4相关肺炎性假瘤临床病理学特征及与CD4^+ T细胞和白介素10的关系分析  

Clinicopathologic features of IgG4-related pulmonary inflammatory pseudotumor and its correlations with CD4^+ T lymphocytes and interleukin-10 expression

作　　者：黄玉钿[1] 谭云山[2] 纪元[2] 曾海英[2] 

机构地区：[1]福建医科大学附属福州市第一医院病理科,福州350009 [2]复旦大学附属中山医院病理科,上海200032

出　　处：《中国免疫学杂志》2015年第12期1699-1703,共5页Chinese Journal of Immunology

摘　　要：目的:研究Ig G4相关肺炎性假瘤(IRPIP)临床病理学特征以及病变与CD4+T细胞和白介素10(IL-10)的关系,探讨Ig G4相关肺炎性假瘤中存在的免疫病理因素。方法:应用免疫组化法检测17例Ig G4相关肺炎性假瘤和15例Ig G4非相关肺炎性假瘤(INPIP)组织中IL-10、CD3、CD20、CD4、CD8的表达,分析这些指标在Ig G4相关肺炎性假瘤和Ig G4非相关肺炎性假瘤中的差异。结果:IRPIP组中CD4阳性细胞数高于INPIP组,差异有统计学意义(P=0.006)。IRPIP组中CD4阳性细胞数/CD8阳性细胞数比值高于INPIP组,差异有统计学意义(P=0.023)。IRPIP组中CD3、CD8、IL-10阳性细胞数高于INPIP组,差异无统计学意义(P>0.05)。IRPIP组中CD20阳性细胞数低于INPIP组,差异无统计学意义(P>0.05)。Ig G4相关性肺炎性假瘤组中Ig G4阳性浆细胞数与IL-10阳性细胞数之间呈正相关(r=0.517),相关性具有统计学意义(P=0.033)。结论:Ig G4相关肺炎性假瘤除了Ig G4阳性浆细胞数量升高,同时伴随着病变背景中CD4+T数量的增加,且Ig G4阳性浆细胞数与淋巴细胞IL-10的表达呈正相关,提示Th2细胞及细胞因子IL-10的分泌是参与Ig G4相关肺炎性假瘤病变的免疫病理因素。Objective： To study the clinicopathologic features of Ig G4-related pulmonary inflammatory pseudotumor（ IRPIP）,and its correlations with CD4^＋T lymphocytes and interleukin-10（ IL-10） expression,and to investigate the immunopathological factors in the disease of Ig G4-related pulmonary inflammatory pseudotumor. Methods： Expressions of IL-10,CD3,CD20,CD4,CD8 were examined by immunohistochemistry in 17 cases of Ig G4-related pulmonary inflammatory pseudotumor tissues and 15 cases of Ig G4-nonrelated pulmonary inflammatory pseudotumor tissues（ INPIP）. To analyze the differences of these indexes expression between IRPIP and INPIP. Results： In group of IRPIP,the CD4^＋T lymphocytes number and the ratio of CD4^＋T lymphocytes number / CD8＋T lymphocytes number were all apparently higher than those in the group of INPIP（ P = 0. 006,0. 023,respectively）. The cells numbers of CD3,CD8,IL-10 positive expression in IRPIP were higer than those in INPIP,and the cells number of CD20 positive expression in IRPIP was lower than that in INPIP,but these differences all had no statistical significance（ P〈 0. 05）. In IRPIP,the number of Ig G4＋plasmacytes was positively related to the number of IL-10＋cell（ r = 0. 517）,the correlation had statistical significance（ P = 0. 033）. Conclusion： The number of CD4^＋T lymphocytes increased in addition to the increased number of Ig G4＋plasmacytes in the lesion background of IRPIP,and the number of Ig G4＋plasmacytes was positively related to the number of IL-10＋cells. It is suggested that the increased number of Th2 lymphocyte and the increased secretion of cytokine IL-10 were are immunopathological factors participated in the disease of IRPIP.

关 键 词：Ig G4 肺炎性假瘤 CD4+T细胞 白介素10 

分 类 号：R392.3[医药卫生—免疫学]