副猪嗜血杆菌毒力因子的研究进展  

RESEARCH PROGRESS ON THE VIRULENCE OF HAEMOPHIL US PARASUIS

作　　者：贾爱卿[1,2] 王贵平 宣华[3] 廖明[1] 

机构地区：[1]华南农业大学兽医学院农业部兽用疫苗创制重点实验室,广州510642 [2]广东海大畜牧兽医研究院,广州511400 [3]广东省农业科学院动物卫生研究所,广州510600

出　　处：《中国动物传染病学报》2015年第4期72-80,共9页Chinese Journal of Animal Infectious Diseases

基　　金：农业部公益性行业科研专项经费项目(201303034)

摘　　要：目前预防和控制革拉斯氏病仍然非常困难,副猪嗜血杆菌是革拉斯氏病的病原菌,定殖于健康猪群的上呼吸道中。了解副猪嗜血杆菌的病原性对于确定其如何引起发病和更好的区分"毒力"和"非毒力"菌株是必要的。副猪嗜血杆菌感染需要粘附和入侵宿主细胞,抵抗巨噬细胞的吞噬,抵抗补体结合并诱发炎症反应。鉴定这些机制过程中的毒力因子在方法上受到一定的限制。关于副猪嗜血杆菌的发病机制的最新进展集中在突变株的构建,然而目前大多数的所谓的毒力因子需要进一步鉴定。Haemophilus parasuis is the aetiological agent of Gl？sser＇s disease. The pathogenicity of H. parasuis is poorly characterised, and prevention and control of Gl？sser＇s disease continues to be challenging. Understanding the pathogenicity of H. parasuis is essential for determining how this bacterium produces disease and to better distinguish between virulent and non-virulent strains. H. parasuis infection requires adhesion to and invasion of host cells, resistance to phagocytosis by macrophages, resistance to serum complement and induction of inflammation. Identification of virulence factors involved in these mechanisms has been limited by difficulties in producing mutants in H. parasuis. Recent advances in understanding the pathogenesis of H. parasuis are due in part to the production of deletion mutants, although most of the potential virulence factors described so far require further characterisation. Data supporting the role of lipooligosaccharide, capsule formation, porin proteins, cytolethal distending toxin and trimeric autotransporters（Vta A） among other molecules in the virulence of H.parasuis have been described. This review provides an overview of the current knowledge of virulence factors of H. parasuis.

关 键 词：副猪嗜血杆菌 毒力因子 革拉斯氏病 猪 

分 类 号：S852.612[农业科学—基础兽医学]