寄生虫烯醇化酶的研究进展  

RESEARCH PROGRESS ON ENOLASE OF PARASITES

作　　者：陈宁[1] 程田[2] 王平[1] 李俊鹏[1] 张延忠 鲁艺[1] 王晓炜[1] 

机构地区：[1]深圳市药品检验所,深圳518057 [2]华南农业大学兽医学院,广州510642 [3]深圳市瑞鹏宠物医院,深圳518000

出　　处：《中国动物传染病学报》2015年第4期81-86,共6页Chinese Journal of Animal Infectious Diseases

基　　金：深圳市科技研发资金知识创新计划项目(JCYJ20130402144215888)

摘　　要：烯醇化酶是糖酵解过程中促进磷酸甘油酸和磷酸烯醇式丙酮酸相互转换的重要催化酶,同时也是存在于真核和原核细胞表面的多功能酶。最近研究发现,它能够激活纤溶酶原,参与病原的感染过程,而且也是主要的免疫刺激性蛋白和药物作用靶点。本文综述当前寄生虫烯醇化酶的研究成果,旨在探讨其作为寄生虫病的诊断、潜在候选疫苗及药物靶点的可能性。Enolase, an important glycolytic enzyme that catalyses the conversion of phosphoglycerate to phosphoenolpyruvate, was identified as a multifunctional protein on the surface of most eukaryotic and prokaryotic cells. Recent studies have revealed that this enzyme could activate the plasminogen,involving in the processes of parasite infection. It is also considered to be a major immunostimulatory protein and drug target. This paper reviews the current research results in parasite enolase, and explores its potential for diagnosis, vaccine candidate and drug targets of parasitic diseases.

关 键 词：寄生虫 烯醇化酶 糖酵解 

分 类 号：S852.7[农业科学—基础兽医学]