尿免疫球蛋白、转铁蛋白、微量白蛋白及β2-微球蛋白的联合检测对妊娠期高血压疾病的临床价值  

Clinic significance of combined measurement of urinary IgG,TRF,mA LB and β2-MG in hypertensive disorders during pregnancy

作　　者：张鑫[1] 赵蕴芝[1] 许文娟[1] 

机构地区：[1]上海市普陀区中心医院妇产科,上海200062

出　　处：《海军医学杂志》2015年第6期511-513,556,共4页Journal of Navy Medicine

摘　　要：目的探讨尿免疫球蛋白(Ig G)、转铁蛋白(TRF)、微量白蛋白(m ALB)、β2-微球蛋白(β2-MG)的联合检测对妊娠期高血压疾病的临床价值。方法免疫比浊法检测73例妊娠期高血压疾病患者尿Ig G、TRF、m Alb、β2-MG的水平,其中重度子痫前期患者29例(Ⅰ组),轻度子痫前期患者20例(Ⅱ组)及妊娠期高血压患者24例(Ⅲ组),并与30例正常妊娠妇女(Ⅳ组)的检测结果进行比较。结果Ⅰ组患者的尿Ig G[(121.86±68.57)mg/L]、TRF[(123.65±52.68)mg/L]、m ALB[(509.55±214.83)mg/L]均显著高于其他各组,差异有统计学意义(P<0.01);Ⅰ组患者的尿β2-MG[(1 144.29±1 010.28)μg/L]高于Ⅲ组和Ⅳ组患者,差异有统计学意义(P<0.05);Ⅱ组患者的Ig G[(42.05±17.45)mg/L]、TRF[(28.51±9.16)mg/L]、m ALB[(103.2±33.05)mg/L]高于Ⅲ组和Ⅳ组,差异有统计学意义(P<0.05)。Ⅱ组患者的尿β2-MG与其他各组比较差异无统计学意义(P>0.05),4项指标在Ⅲ组和Ⅳ组患者之间的差异无统计学意义(P>0.05)。Ⅰ、Ⅱ组患者的4项指标异常率高于Ⅲ组和Ⅳ组,差异有统计学意义(P<0.05)。结论随着妊娠期高血压疾病病情加重,尿Ig G、TRF、m Alb、β2-MG的排泄量逐渐升高,且随着病情加重,可出现多种尿蛋白的同时升高。联合检测尿Ig G、TRF、m Alb、β2-MG对判断妊娠期高血压疾病的严重程度有一定的临床价值。Objective To investigate the clinic significance of urinary immunoglobulin G（ Ig G）,transferring（ TRF）,microalbumin（ m ALB）,β2-microglobulin（ β2-MG） in the diagnosis of hypertensive disorders during pregnancy. Methods Immunoturbidimetry was used to detect urinary Ig G,TRF,m ALB and β2-MG in 73 patients with hypertensive disorders complicated with pregnancy. Of the 73 patients,29 with severe preeclampsia were designated as group I,20 with mild preeclampsia were designated as group Ⅱand 24 patients with gestational hypertension were designated as group Ⅲ. Another 30 healthy pregnant women were selected as the control group（ group Ⅳ）. Results The levels of urinary Ig G[（ 121. 86 ± 68. 57） mg / L],TRF[（ 123. 65 ± 52. 68） mg / L],m ALB[（ 509. 55± 214. 83） mg / L] in the patients of groupⅠ were significantly higher than those of the other 3 groups（ P〈0. 01）. The level of urinaryβ2-MG[（ 1 144. 29 ± 1 010. 28） μg / L]of the patients in group Ⅰwas higher than those of the patients in groups Ⅲ and group Ⅳ,with statistical significance（ P〈0. 05）. The levels of urinary Ig G [（ 42. 05 ± 17. 45） mg / L],TRF [（ 28. 51 ± 9. 16） mg / L] and m ALB[（ 103. 27 ± 33. 05） mg/L]in the patients of group II were higher than those of groups Ⅲ and group Ⅳ,with statistical significance（ P〈0. 05）. There was no statistical significance in the level of urinary β2-MG for the patients of group II,when comparisons were made with the other 3 groups（ P〉0. 05）. There were no significant differences in the 4 indicators,when comparisons were made between group Ⅲ and groupⅣ（ P〉0. 05）. Abnormal rates of the 4 indicators in the patients of groups Ⅰ and Ⅱwere significantly higher than those of groups Ⅲ and Ⅳ（ P〈0. 05）. Conclusion With the deterioration of hypertensive disorder during pregnancy,the excretion of urinary Ig G,TRF,m ALB and β2-MG gradually increased and simultaneously there was an increase of a variety of urine protei

关 键 词：妊娠期高血压疾病 尿免疫球蛋白 尿转铁蛋白 尿微量白蛋白 尿Β2-微球蛋白 

分 类 号：R714.252[医药卫生—妇产科学]