脂联素在系统性红斑狼疮患者体内的表达及意义  

The Expression of The Adiponectin in Systemic Lupus Erythematosus

作　　者：彭英兰[1] 高锦团[2] 

机构地区：[1]呼和浩特市第一医院内分泌科,内蒙古呼和浩特010030 [2]福建医科大学附属第二医院免疫内科,福建泉州362000

出　　处：《内蒙古医学杂志》2015年第9期1037-1039,共3页Inner Mongolia Medical Journal

摘　　要：目的检测系统性红斑狼疮(Systemic Lupus Erythematosus,SLE)患者血清、尿脂联素浓度,并探讨脂联素与该病的关系。方法使用酶联免疫吸附法(ELISA)测定系统性红斑狼疮患者以及正常对照组血清、尿脂联素浓度。结果平均血清、尿脂联素水平在SLE肾损害组为(8.22±3.78)mg/L、(36.19±25.07)μg/L,非肾损害组(3.39±1.72)mg/L、(7.61±4.72)μg/L,均高于正常对照组的(1.95±0.88)mg/L及(1.92±1.11)μg/L,且肾损害组脂联素浓度明显高于非肾损害组;平均血清、尿脂联素水平在SLE活动组为(7.75±4.13)mg/L、(29.36±25.17)μg/L,稳定组为(3.87±2.13)mg/L、(7.53±3.78)μg/L,均高于正常对照组的(1.95±0.88)mg/L、(1.92±1.11)μg/L,且血清脂联素在SLE活动组明显高于SLE稳定组,差异均有统计学意义(P<0.05)。结论由于大量研究提示脂联素是一种保护性蛋白因子,该实验结果提示脂联素浓度在SLE肾损害组及活动组明显升高,可能起到延缓疾病的进展尤其延缓狼疮性肾炎的发生。Objective To investigate the levels of serumal and urinous adipenectin in Systemic Lupus Erythematosus and to explore their roles in this disease.Methods ELISA technique were employed to determine the serumal and urinous adiponectin concentration in the SLE patients and healthy group.Results The concentration of serumal and urinous adiponectin in SLE patients especially who suffer from kidney impairment and activing-phase are much higher than the stable-phase SLE patients and the healthy group.Condusion Adiponectin is a protective cytokine,it indicates that the higher level of adiponectin in SLE patients especially who suffer from kidney impairment and activing-phase may delay the disease especially lupus nephritis.

关 键 词：脂联素 系统性红斑狼疮 活动期 肾损害 

分 类 号：R593.241[医药卫生—内科学]