慢性肾脏病皮肤瘙痒的发病机制、特点及治疗  

The Pathogenesis,Characteristics and Treatment of Pruritus from Chronic Kidney Disease

作　　者：桂保松[1] 马姗[1] 姚智慧[1] 

机构地区：[1]西安交通大学第二附属医院肾病科,陕西西安710004

出　　处：《中国医学文摘（皮肤科学）》2015年第6期598-602,共5页China Medical Abstracts(Dermatology)

摘　　要：在慢性肾脏病患者中,皮肤瘙痒是很常见的症状,它使患者非常痛苦。尤其在慢性肾脏病终末期(ESRD),尿毒症皮肤瘙痒(UP)严重影响了患者的生活质量和睡眠质量,甚至引起抑郁。目前,UP的发病机制尚未完全明确,相关研究发现可能与皮肤干燥、全身炎症反应、血浆甲状旁腺激素水平升高、钙磷代谢紊乱等因素有关。UP的临床表现多样,应充分考虑患者是否合并有其他系统疾病或皮肤病。UP没有统一的治疗标准,包括局部用药、口服药物、血液透析、B型紫外线照射等治疗方法。Pruritus is a common and distressing symptom in patients with chronic kidney disease. Uremic pruritus （UP） affects seriously sleep, depression and quality of liafe （QOL） specially in end-stage ranal disease（ESRD）. The pathogenesis of UP is largely unclear, although several theories on etiologic or contributing factors have been proposed including increasd systemic inflammation; abnormal serum parathyroid hormone, calcium,and phosphorus levels. UP can present somewhat variably. A variety of alternative systemic or dermatologic conditions should be considered,especially in patients with asymmetric pruritus or other atypical features. There are no formal published guidelines regarding the treatment of UP; however, many reviews have pubtished treatment recommendations such as topical treatment, systemic treatment,hemodialysis, UVB.

关 键 词：慢性肾脏病 瘙痒 临床特点 发病机制 治疗 

分 类 号：R692[医药卫生—泌尿科学] R758.31[医药卫生—外科学]