大剂量N-乙酰半胱氨酸治疗肺间质纤维化疗效观察  

Treet effect observe on N-acetyl semifinished amino acid effect pulmonary fibrosis

作　　者：马显军[1] 李水霞[1] 张毅[1] 

机构地区：[1]包头医学院第二附属医院,内蒙古包头014030

出　　处：《疾病监测与控制》2015年第12期861-862,共2页Journal of Diseases Monitor and Control

摘　　要：目的观察大剂量N-乙酰半胱氨酸(NAC)治疗肺间质纤维化的治疗效果。方法肺间质纤维化患者70例随机分为病例组36例,对照组34例。病例组给予平喘化痰治疗,观察组在上述治疗基础上,给予NAC 600mg/次,3次/d口服,疗程均为6个月,比较2组治疗前后FEV1/FVC(第1秒用力呼气量与用力肺活量的比)、VC%(肺活量占预计值的百分比)、DLCO%(肺一氧化碳弥散量占预计值的百分比)、pa O2及TGF-β1(血清转化生长因子)水平。结果病例组总有效率高于对照组;病例组治疗后FEV1/FVC、VC%、DLCO%、pa(O2)较治疗前增加,血清TGF-β1较治疗前降低(P<0.05),对照组治疗前、后差异无统计学意义(P>0.05)。结论大剂量N-乙酸半胱氨酸可降低肺间质纤维化患者血清TGF-β1水平,抑制TGF-β1的致纤维化作用,改善患者肺功能及pa O2。Objective To observe the curative effect of high-dose N-acetyl semifinished amino acid for the treatment of pulmonary fibrosis. Methods 70 patients were randomly divided into 36 cases of treatment group, and 34 at control group. The control group was given relieving cough and reducing phlegm treatment. On this basis, the treatment group was given extra oral drug at NAC, 600rag per tine, 3thnes per day. Then after 6morths of treatment course, compare the FEV1/FVC before and after treatment. DLCO%, PaO2 and TGF-β1 of the two group. Results the total curative rate at treatment group is higher than that of control group. The FEV1/FVC, V%, DLCO%, PaO2 are increased after treatment; the serum level at TGF-β1 is reduced after treatment （P〈0.05）. There is no statistically significant difference between and after treatment. Conclusion high dose of NAC can help reducing the pulmonary fibrosis patients＇ serum level of TGF-β1 preventing the TOF-β1＇s fibrosis effect, and improving patients＇ lung-fimction and Pa02.

关 键 词：肺间质纤维化 N-乙酰半胱氨酸 转化生长因子-Β1 

分 类 号：R563.13[医药卫生—呼吸系统]