磁共振波谱定量测量肝炎所致肝硬化背景肝脏组织代谢的研究  

The study of background metabolites in the River after chronic B hepatitis using MRS

作　　者：陆伦[1] 贾宁阳[1] 蔡权宇 龙行安[1] 程红岩[1] 

机构地区：[1]第二军医大学附属东方肝胆外科医院放射科,上海200438

出　　处：《实用放射学杂志》2015年第12期1963-1966,共4页Journal of Practical Radiology

摘　　要：目的 探讨磁共振单体素MRS技术结合LC-Model绝对定量慢乙肝后代谢物在预测慢乙肝转归的可行性。方法 对11例健康志愿者和17例慢乙肝稳定及15例慢乙肝进展的患者行常规MRI和MRS检查，利用LC-Model波谱软件分别对代谢物Cho、Lip及Cho/Lip定量测量并进行比较。结果 Cho（a.u.）分别为7.58±5.05, 11.26±7.21, 17.67±11.72 3组之间有统计学意义；Lip（a.u.）分别为625.32±694.12, 329.28±412.57, 422.65±471.45，慢乙肝稳定组与进展组之间无明显统计学意义，与对照组有统计学意义；Cho/Lip的比值在慢乙肝稳定组与进展组无意义，与对照组比较有统计学意义。结论 单体素MRS结合LC-Model技术能够分析慢乙肝后病理改变的代谢物的变化；在预测慢乙肝后进展方面有一定的意义。Objective To explore magnetic resonance single voxel magnetic resonance spectroscopy （MRS） technology combined LC-Model to the absolute quantification of the metabolites in liver cirrhosis after chronic B hepatitisand, and to predict the probability of prognosis. Methods 11 healthy volunteers,17 patients stable after chronic B hepatitis （stable group） ,and 15 patients progress after chronic B hepatitis （progress group） underwent routine MRI and MRS scanning,and LC-Model spectrum software was used to quantificate Cho, Lip and Cho/Lip in three groups. Results Cho（ a. u. ） values were 7.58±5.05,11.26 ±7.21,17.67 ±11.72 respectively. There were significant differences on Cho values in three groups. Lip（a. u. ） values were 625.32±694.12,329.28±412.57, 422.65 ± 471.45 respectively. There was no difference between stable group and progress group, but differences existed between stable group or progress group and control group. Cho/Lip value was no difference between stable group and progress group,but existed between stable group or progress group and control group. Conclusion Single voxel MRS technique combined LC-Model can analyze changes in metabolites after chronic B hepatitis. MRS has some predictions in liver cirrhosis after chronic B hepatitis transform to progress.

关 键 词：磁共振成像 磁共振波谱成像 慢乙肝 

分 类 号：R445.2[医药卫生—影像医学与核医学] R512.6[医药卫生—诊断学]