大承气冲剂对腹内感染患者重要脏器功能的影响  

Effect of Dachengqi Granules on Functions of Various Visceras in Patients Suffering from Intra-abdominal Infections

作　　者：张兴洲[1] 解基良[1] 张楠[1] 单涛[1] 闫瑞鹏[1] 宋媛[1] 桑伟岗 

机构地区：[1]天津市南开医院,天津300100

出　　处：《中国中西医结合外科杂志》2015年第6期556-559,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：天津市卫生局科技基金(11KG129)

摘　　要：目的:观察大承气冲剂对腹内感染患者重要脏器功能的影响。方法:将60例腹内感染患者随机分为对照组30例和中药组30例;对照组给予西医常规治疗结合安慰剂,中药组给予西医常规治疗辅加大承气冲剂,疗程为5 d,观察各组患者主要脏器功能变化。结果:中药组与对照组相比,患者的肝功能(TBIL、AST、ALT)、肾功能(BUN、肌酐)及代谢功能(血糖、甘油三酯、胆固醇)变化无显著差异(P均>0.05);中药组的排气时间为(14.9±2.7)d,排便时间为(20.7±2.3)d,明显短于对照组的(19.3±3.5)d和(26.1±4.1)d,有统计学意义。中药组的内毒素含量在第5 d为(0.105±0.027),较对照组(0.147±0.023)明显下降。中药组的氧和指数在第5 d为(255.44±18.18),较对照组(222.76±15.15)明显升高。差异有统计学意义。结论:大承气颗粒在短时间内对腹内感染患者的肝功能、肾功能、代谢功能无明显的影响;但大承气颗粒可短时间内减轻腹内感染患者肺肠的损伤,有助于肺肠功能的恢复。ObjectiveTo observe the effect of Dachengqi granules on functions of certain visceras in pa-tients with intra-abdominal infection.MethodsSixty patients with abdominal infection were randomly divid-ed into the control group（30 cases）and traditional Chinese medicine group（30 cases）; the control group was giv-en conventional western treatment combined with placebo, and traditional Chinese medicine group was given con-ventional western medicine treatment combined with Dachengqi granules. The changes of main viscera functionin patients of two groups were observed and compared continuously in five days.ResultsThe liver function（TBIL, AST, ALT）, kidney function（BUN and creatinine） and metabolic function（blood sugar, triglyceride, choles-terol） of patients in traditional Chinese medicine group were not significantly different from those in the controlgroup（P〈0.05）; Exhaust and defecation time in traditional Chinese medicine group was obviously shorter thanthat in control group, and the difference was statistically significant（ Exhaust time 14.9 ± 2.7vs19.3 ± 3.5,P〈0.05;and defecation time 20.7±2.3vs26.1±4.1,P〈0.05）. Endotoxin content of traditional Chinese medicinegroup was significantly decreased in the fifth day than that in the control group, and the difference was statisti-cally significant（0.105±0.027vs0.147±0.023,P〈0.05）. The oxygenation index of traditional Chinese medicinegroup was obviously higher in the fifth day than that of control group, and the difference was statistically signifi-cant（255.44±18.18vs222.76±15.15,P〈0.05）.ConclusionDachengqi granules can not obviously affect theliver function, renal function and metabolic function of patients with intra-abdominal infection in a short periodtime. But Dachengqi granules can reduce the intestinal and lung injury,and improve the recovery of intestinaland lung function.

关 键 词：重症腹内感染 大承气颗粒 脏器功能 内毒素 

分 类 号：R631[医药卫生—外科学]