血清CRP、Anti-CCP及RF检测在类风湿关节炎诊断中的应用  

Application of combined detection of C-reaction protein(CRP),anti-cyclic citrullinated peptide antibody(CCP)and reumatoid factor(RF)in rheumatic arthritis diagnosis

作　　者：宋月娟[1] 哈小琴[1] 冯强生[1] 朱晓红[1] 董菊子[1] 

机构地区：[1]兰州军区兰州总医院检验科,甘肃兰州730050

出　　处：《西北国防医学杂志》2015年第12期805-807,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的：探讨C反应蛋白、抗环瓜氨酸肽抗体及类风湿因子在类风湿关节炎诊断中的应用。方法：选择2011-09～2013-09来我院就诊的类风湿关节炎患者100例,关节疼痛的非类风湿关节炎患者100例,分别用乳胶增强免疫比浊法测定C反应蛋白和类风湿因子,用酶联免疫吸附试验测定抗环瓜氨酸肽抗体,分析两组患者中C反应蛋白、抗环瓜氨酸肽抗体及类风湿因子的相关性。结果：C反应蛋白对类风湿关节炎的敏感性为67%,特异性为83%,抗环瓜氨酸肽抗体对类风湿关节炎的敏感性为63%,特异性为97%,类风湿因子对类风湿关节炎的敏感性为86%,特异性为75%,C反应蛋白、抗环瓜氨酸肽抗体及类风湿因子三者联合检测的敏感性为63%,特异性为100%。结论：在类风湿关节炎的诊断中,C反应蛋白的敏感性高于类风湿因子和抗环瓜氨酸肽抗体,但特异性低于类风湿因子和抗环瓜氨酸肽抗体,三者联合检测有助于类风湿关节炎的早期诊断和病情控制。Objective：To investigate the application of the combined detection of C-reaction protein（CRP）,anti-cyclic citrullinated peptide antibody（CCP）and reumatoid factor（RF）in rheumatic arthritis（RA）diagnosis.Methods：One hundred patients with rheumatic arthritis and 100 arthralgia without RA were selected during Sep.2011 to Sep.2013 in inpatients of our hospital.CRP and RF were detected by Latex-enhanced immunoturbidimetry assay,and CCP were tested used ELISA,the difference in the two groups were analysed.Results：The sensitivity and specificity of three methods for the diagnosis of rheumatic arthritis,CRP was 67%and 83%,anti-CCP was 63%and 97%,RF was 86%and 75%,respectively.The combination of CRP,anti-CCP and RF detection presented with the highest sensitivity（63%）and specificity（100%）for the diagnosis of RA.Conclusion：CRP has more sensitivity for the diagnosis of RA than that of CCP and RF with less specificity,the combination of three methods is helpful for early diagnosis and control of rheumatic arthritis.

关 键 词：类风湿关节炎 C反应蛋白 抗环瓜氨酸肽抗体 类风湿因子 诊断 

分 类 号：R593.22[医药卫生—内科学]