高原高寒环境对大鼠胃黏膜损伤的影响及IL-4参与作用研究  被引量:1

Contributory roles of IL-4 in gastric mucosal injury of rats under cold plateau environment

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作  者:代忠明[1] 张伟平[1] 聂占国[1] 

机构地区:[1]兰州军区乌鲁木齐总医院全军消化专科中心,新疆乌鲁木齐830000

出  处:《西北国防医学杂志》2015年第12期810-812,共3页Medical Journal of National Defending Forces in Northwest China

基  金:军队"十一五"科技攻关课题资助项目(08G012)

摘  要:目的:观察高原高寒环境对大鼠胃黏膜的影响及对大鼠血清和胃组织中IL-4表达水平的变化。方法:SD大鼠65只,雄性,随机分成高原环境组、高原高寒环境组与对照组,观察胃黏膜变化并测定大鼠血清和胃组织中IL-4表达水平。结果:高原环境组与高原高寒环境组大鼠胃黏膜产生不同程度的损伤,分别与对照组比,模型组大鼠血清和胃组织中IL-4表达水平均有显著差异(P<0.01)。高原高寒环境组与高原环境组比较,大鼠血清及胃组织IL-4表达水平也有显著差异(P<0.01)。结论:高原高寒环境对大鼠血清胃组织IL-4含量有显著影响并损伤胃黏膜。Objective:To observe the influence of cold plateau environment on the gastric mucosa and the changes of expression level of IL-4in serum and gastric tissue of rats.Methods:Sixty-five SD rats,all male,were randomly divided into the plateau environment group,cold plateau environment group and control group,to observe the changes of gastric mucosa and serum and gastric tissue IL-4expression level.Results:Different degrees of injury in gastric mucosa of rats were found in plateau environment group and cold plateau environment group,respectively.Compared with control group,the expression level of serum and gastric tissue IL-4 were significantly different in model group(P〈0.05).There were significant difference in serum and gastric tissue IL-4expression between the cold plateau environment group with the environment of plateau group(P〈0.05).Conclusion:The cold plateau environment has a significant effect on the content of IL-4in serum and gastric tissue,and may result in gastric mucosal injury in rats.

关 键 词:高原高寒环境 胃黏膜损伤 IL-4 

分 类 号:R339.5[医药卫生—人体生理学]

 

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