LTE4和鼻咽分泌物ECP对毛细支气管炎治疗和预后的影响  

Effects of LTE4 and nasopharyngeal secretions ECP on the treatment and prognosis of bronchiolitis

作　　者：侯秀玲[1] 王敬敏[1] 刘冬梅[1] 李雪萍[1] 

机构地区：[1]河北省保定市第二中心医院儿科,072750

出　　处：《检验医学与临床》2015年第24期3637-3638,3642,共3页Laboratory Medicine and Clinic

基　　金：河北省科学技术研究与发展攻关计划资助项目(072761414)

摘　　要：目的探讨尿白三烯E4(LTE4)和鼻咽分泌物嗜酸性细胞阳离子蛋白(ECP)对呼吸道合胞病毒(RSV)毛细支气管炎患儿治疗和预后的影响。方法选取2014年1月至2015年3月保定市第二中心医院儿科住院RSV毛细支气管炎患儿79例作为研究对象,设为RSV毛细支气管炎组,均采用常规西医治疗,选取同期涿州市健康小儿75例作为健康对照组,均检测LTE4和ECP水平,观察治疗前、后和两组之间以上指标变化情况。结果治疗前,治疗后3、7、14、21dRSV毛细支气管炎患儿LTE4水平分别为(176.35±78.24)、(164.35±71.45)、(112.45±54.62)、(67.55±25.24)、(41.35±10.57)pg/mL;ECP水平分别为(98.56±61.57)、(88.34±43.64)、(61.46±24.66)、(50.41±17.84)、(34.68±12.54)μg/L,治疗后明显低于治疗前,治疗前、后比较差异均有统计学意义(P<0.05)。治疗前健康对照组受试者LTE4、ECP水平均明显低于RSV毛细支气管炎患儿,组间比较差异有统计学意义(P<0.05);RSV患儿治疗末LTE4、ECP水平与健康对照组受试者比较,差异无统计学意义(P>0.05)。结论 LTE4和鼻咽分泌物ECP能反映出RSV毛细支气管炎患儿的治疗进展和预后情况,在临床上有一定指导意义。Objective To investigate the effects of urinary leukotriene E4（LTE4）and nasopharyngeal secretions eosinophil cationic protein（ECP）on the treatment and prognosis of children with respiratory syncytial virus（RSV）bronchiolitis.Methods 79 children with RSV bronchiolitis hospitalized in Department of Paediatrics,Second Central Hospital of Baoding,Baoding from January 2014 to March 2015 were enrolled as RSV bronchiolitis group,and were treated by conventional therapy.79 healthy children of Zhuozhou City were selected as normal control group.The levels of LTE4 and ECP in the two groups were detected,their changes were observed before and after the treatment.Results The LTE4 levels of RSV bronchiolitis group were（176.35±78.24）,（164.35±71.45）,（112.45±54.62）,（67.55±25.24）and（41.35±10.57）pg/mL respectively before and 3,7,14,21 dafter the treatment,and the ECP levels respectively were（98.56±61.57）,（88.34±43.64）,（61.46±24.66）,（50.41±17.84）and（34.68±12.54）μg/L.After the treatment,the levels of LTE4 and ECP significantly decreased（P〈0.05）.Before the treatment,the levels of LTE4 and ECP of RSV bronchiolitis group were significantly higher than those of normal control group（P〈0.05）.After the treatment,there was no differences of LTE4 and ECP levels between RSV bronchiolitis group and normal control group（P〉0.05）.Conclusion The levels of LTE4 and ECP can reflect the treatment progress prognosis of children with RSV bronchiolitis,which have a certain significance in clinical practice.

关 键 词：尿白三烯 鼻咽分泌物嗜酸性细胞阳离子蛋白 呼吸道合胞病毒 毛细支气管炎 临床效果 

分 类 号：R725.6[医药卫生—儿科]