细菌荚膜多糖的研究进展  

Research progress on bacterial capsular polysaccharide

作　　者：李天一[1,2] 王英锋[1] 张玫[2,3] 

机构地区：[1]首都师范大学化学系,北京100004 [2]传染病预防控制国家重点实验室,中国疾病预防控制中心传染病预防控制所,北京102206 [3]感染性疾病诊治协同创新中心,杭州310003

出　　处：《中国人兽共患病学报》2015年第12期1171-1176,共6页Chinese Journal of Zoonoses

基　　金：国家自然科学基金面上项目(No.81471919);中国疾病预防控制中心青年科研基金(No.2014A101)联合资助~~

摘　　要：本文对荚膜多糖进行了概述,综述近年来细菌荚膜多糖相关的研究进展,并从理化性质与生物学功能的角度出发,总结了近年来荚膜多糖提取、分离、纯化等方面的研究,重点介绍了与荚膜多糖结构相关的研究进展。本文为进一步研究细菌致病性、分型机制提供必要的方法,为疫苗的设计提供基础数据,对加强致病菌的防控具有重要意义。The purpose of this review is to summarize novel research progress on capsular polysaccharide（CPS）,especially the related research progresses on bacterial capsular polysaccharide（CPS）are reviewed.The definition,physicochemical properties and biological functions of CPS were summarized in this review article.Study progresses on extraction,isolation and purification of CPS were discussed,especially those reports and results related to structural analysis.This information can contribute to the further research on the pathogenic and typing mechanism by the investigation of the relationship between CPS structures and pathogenicity and also the survival ability.In addition,the structures of CPS will be the basic data to prompt the design of both general and target vaccines.All of these play important roles on the prevention and control of pathogen infection.

关 键 词：荚膜多糖 提取 分离 纯化 理化性质 

分 类 号：R378[医药卫生—病原生物学]