依托考昔致固定性药疹国内首报及文献复习  

The first case of fixed drug eruption caused by etoricoxib in China and related references review

作　　者：董盈盈[1] 陈岚[1] 段铱 胡伟[1] 张艳红[1] 邓云华[1] 陈兴平[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院皮肤科,武汉430030

出　　处：《实用皮肤病学杂志》2015年第6期419-421,共3页Journal of Practical Dermatology

摘　　要：报道1例依托考昔致固定型药疹患者,男,43岁。因眼内眦、唇部、颊黏膜及龟头红斑、水疱、糜烂,伴痛痒12 h就诊。查体见双眼内眦皮肤小片淡红斑;双唇见大片水肿性红斑或紫红斑,少许水疱,口腔颊黏膜见小片状水肿性红斑;龟头部见大片红斑、糜烂和渗液。既往有3次口服依托考昔后均出现过类似皮损病史。据此诊断为固定型药疹(依托考昔所致)。患者停用依托考昔,经抗过敏与对症治疗后皮损逐渐消退,局部遗留持久性色素沉着斑。警示临床医师应注意依托考昔所致固定型药疹的皮肤不良反应。A case of fixed drug eruption caused by etoricoxib was reported here. A 43-year-old male presented with erythema, blisters, erosions on the skin of his inner canthi, mucosal membranes of the lips, oral as well as the balanus, accompanied by pruritus and pain for 12 hours. Dermatologic examination showed small pale erythema on his inner canthi; large violaceous or edematous erythema with several blisters were seen on his lips; small edematous erythema on the buccal mucosa; large erythema, erosions and exudation on his balanus. The patient had had three episodes with similar skin lesions after taking etoricoxib this time before. Then he was diagnosed as fixed drug eruption caused by etoricoxib. After etoricoxib was withdrawn and antihistamines as well as symptomatic treatment were adopted, the skin lesions resolved gradually, as well as long-last residual hyperpigmentation leaved. This case alerts clinicians to pay attention to the adverse reaction of fixed drug eruption caused by etoricoxib.

关 键 词：药疹 固定性 依托考昔 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]