血清中IgA/C3比值在IgA肾病诊断预测中的价值及其与IgA肾病临床及病理联系  

Value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and its correlation with the clinicopathological features

作　　者：祝爽爽 李永强[1] 周树录[1] 魏清柱[2] 邓康平[1] 王晓红[1] 李宾[1] 刘江欢[2] 刘新宇[1] 张瑛[1] 邵小飞[1] 刘爱群[1] 吴碧芳[1] 赵志红[1] 徐小蒙 林韩翡 刘琴[1] 黎嘉敏[1] 王红蕾[1] 周琴[1] 朱超亚[1] 吕道远[1] 夏悦[1] 邹和群[1] 

机构地区：[1]南方医科大学第三附属医院肾内科//泌尿疾病研究所,广东广州510630 [2]南方医科大学第三附属医院病理科,广东广州510630

出　　处：《南方医科大学学报》2015年第12期1683-1688,共6页Journal of Southern Medical University

基　　金：国家自然科学基金(81270840)~~

摘　　要：目的探讨血清IgA/C3水平在IgA肾病诊断预测中的价值,及其与IgA肾病临床、病理之间的关系。方法收集自2009年11月~2015年2月于南方医科大学第三附属医院肾活检诊断的66例IgA肾病,111例其他肾小球疾病,40例无肾脏病的健康体检者。使用CRM470调整后的标准化免疫比浊法检测患者血清中IgA、C3,并计算IgA/C3比值。参照牛津分级及Lee氏分级分别对IgA肾病患者进行病理学分级。在比较血清IgA、IgA/C3比值在预测IgA肾病的价值时,通过绘制ROC曲线,并计算曲线下面积。结果 IgA肾病患者血清IgA/C3比值较其他肾小球疾病组和健康对照组明显升高,其ROC曲线下面积为0.776。血清IgA/C3比值升高与IgA肾病病理损伤程度无明显相关性。结论在未开展肾活检的医院及不接受行肾活检的患者,血清IgA/C3比值在IgA肾病诊断中可起一定辅助作用。Objective To investigate the value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and explore its relationship with the clinicopathological features of the patients. Methods Sixty- six patients with IgA nephropathy, 111 with other glomerular diseases, and 40 healthy control subjects without kidney disease were tested for serum IgA and C3 levels using CRM470 adjusted standardized immune turbidimetric method, and the IgA/C3 ratio was calculated. According to Oxford and Lee＇s classification criteria, we analyzed the pathological grades of the renal biopsy samples from patients with IgA nephropathy. The ROC curve was used to assess the value of serum IgA and IgA/C3 ratio in predicting IgA nephropathy.Results Patients with IgA nephropathy had an elevated serum IgA/C3 ratio than those with other glomerular diseases and the control subjects, with an area under the ROC curve of 0.776. An elevated serum IgA/C3 ratio was not found to significantly correlate with the pathological grade of renal biopsy samples in patients with IgA nephropathy. Conclusion In the absence of renal biopsy findings, serum IgA/C3 ratio can help in the diagnosis of IgA nephropathy.

关 键 词：IGA肾病 血清IgA/C3比值 血清IGA 

分 类 号：R692.3[医药卫生—泌尿科学]