多指标综合评分法优选补正续骨颗粒最佳提取工艺  

Optimization of extraction technology for Buzheng Xugu granules by multi-index comprehensive evaluation method

作　　者：田原[1] 樊晖[1] 关雪峰[1] 张锡玮[1] 孙科峰[1] 

机构地区：[1]辽宁中医药大学附属医院,沈阳110032

出　　处：《长春中医药大学学报》2015年第6期1134-1136,共3页Journal of Changchun University of Chinese Medicine

基　　金：辽宁省科学技术计划项目(2013226012);辽宁中医药大学"杏林学者青蓝工程"

摘　　要：目的优选补正续骨颗粒的提取工艺。方法采用L9(34)正交试验法,以出膏率为考察指标,优选最佳水提取工艺,以川续断皂苷Ⅵ与柚皮苷总含量及出膏率综合评分为评价指标,优选最佳乙醇提取工艺。结果最佳水提取工艺为加6倍量水,提取2次,每次提取1 h。最佳乙醇提取工艺为加6倍量60%乙醇,提取3次,每次2 h。结论优选的提工艺稳定可行,适用于补正续骨颗粒的工业化生产。Objective To optimize extraction technology of Buzheng Xugu granules. Methods Orthogonal experimental design was adopted,dry extract rate as evaluation index,to optimize water extraction technology,contents of asperosaponin; naringin and dry extract as evaluation index,to optimize ethanol extraction technology. Results Optimal water extraction technology was extracted 2 times with 6 times the amount of water for 1 h per time; optimal ethanol extraction technology was extracted 3 times with 6 times the amount of 60% ethanol for 2 h per time. Conclusion This optimized extraction technology was stable,feasible,suitable for Buzheng Xugu Granules production.

关 键 词：补正续骨颗粒 川续断皂苷Ⅵ 柚皮苷 正交试验 

分 类 号：R284.2[医药卫生—中药学]