骨刺消合剂对膝骨关节炎患者血清中超氧化物歧化酶、一氧化氮及肿瘤坏死因子α的影响  

Gucixiao on SOD,NO and TNF-α in knee osteoarthritis patients

作　　者：傅强[1] 牛锋[1] 张利勇[1] 杨昌杰[1] 殷利民[1] 田涛[1] 

机构地区：[1]南京中医药大学扬州附属医院骨伤科,江苏扬州225002

出　　处：《长春中医药大学学报》2015年第6期1230-1232,共3页Journal of Changchun University of Chinese Medicine

基　　金：江苏省扬州市2012科技攻关-社会发展科技攻关项目(2012138)

摘　　要：目的观察骨刺消合剂对膝骨关节炎患者血清中SOD、NO和TNF-α的影响。方法将60例膝骨关节炎患者随机分为2组,治疗组30例,服用骨刺消合剂;对照组30例,采用膝关节腔注射玻璃酸钠,观察2组治疗前后血清中SOD、NO和TNF-α的影响。结果 2组血清SOD含量均提高,NO和TNF-α的含量均下降,与治疗前比较有统计学意义(P<0.01,P<0.05),且治疗组优于对照组(P<0.05)。结论骨刺消合剂能保护软骨及其基质免受继发性侵害,延缓关节软骨的退变速度,改善关节软骨的营养和代谢,促进软骨修复,防治膝骨关节炎的发生。Objective To observe the effect of Gucixiao on serum SOD,NO and TNF- α in Knee Osteoarthritis Patients. Methods The 60 KOA patients were randomized into 2 groups： treatment group（ n = 30,treated with Gucixiao） and control group（ n = 30,treated with intra-artivular injection of sodium hyaluronate）. The serum SOD,NO and TNF- α contents were monitored. Results SOD contents in both groups were inclined to elevate,while the NO and TNF- αcontents,which were close to normal. When compared with that before treatment and with that the control group,there were statistical difference of significance（ P〈0. 01,P〈0. 05）. Conclusion The preventive and curative effects of Gucixiao on KOA may be realized by promoting repairing the cartilage due to the improvement of the nutrient and metabolic condition of the arthrodial cartilage via slowing the cartilage degeneration,as this medicine could protect the cartilage and its ground substance from secondary impairment.

关 键 词：膝骨关节炎 骨刺消合剂 玻璃酸钠 超氧化物歧化酶 

分 类 号：R274.9[医药卫生—中西医结合]