不同妊娠时机选择对系统性红斑狼疮患者妊娠结局的影响分析  

An Analysis of Influence of Different Pregnancy Timing on Pregnancy Outcome of Patient with SLE

作　　者：何春媚[1] 张科[1] 林梅[1] 

机构地区：[1]广东省梅州市人民医院,梅州514031

出　　处：《数理医药学杂志》2016年第1期22-23,共2页Journal of Mathematical Medicine

摘　　要：目的：探讨妊娠时机选择对系统性红斑狼疮患者妊娠结局的影响.方法：选取2009年2月~2015年2月在某院就诊的妊娠合并SLE的50例孕妇为研究对象,根据其妊娠时机不同,将其分为随意妊娠组（对照组）和选择妊娠组（实验组）,两组患者在基本资料比较中显示差异不具有统计学意义,两组数据具有临床可比性.比较两组患者妊娠结果.结果：对两组患者新生儿妊娠结局比较结果显示,实验组婴儿的活产率、早产率、胎儿宫内生长受限、胎死宫内情况与对照组相比差异均有统计学意义（P 〈0.05）.对两组患者妊娠期SLE病情变化结果显示,实验组24例患者中,病情活动人数占33.3%;对照组26例患者中,病情活动人数占92.3%,P〈0.05显示差异具有显著统计学意义.实验组轻度者7例,中度者1例,无重度者;对照组轻度者14例,中度者6例,重度者4例.且对照组较实验组病情加重明显.结论：对SLE患者进行指导妊娠,注意妊娠时机的选择及加强母婴监护,合理用药等可以显著降低SLE的发生及改善母婴结局.Objective:To investigate the effect of the timing of pregnancy on the pregnancy outcome of patients with systemic lupus erythematosus.Methods:50pregnant women who were treated in some hospital during the period from February 2009 to February 2015 were selected as the research object.According to the differencein pregnancy timing,they were divided into random pregnancy group(the control group)and selective pregnancy group(the experimental group).The difference between the two groups in basic data was not statistically significant,the data of the two groups were clinically comparable.Pregnancy outcome was compared between the two groups.Results:According to the comparison between the 2groups in pregnancy,the differences between the 2group in the rate of live births,premature delivery,fetal intrauterine growth restriction and intrauterine fetal death were statistically significant(P<0.05).According to the lesion of SLE in the two groups,of all the 24 patients in experiment group,the number of patientwith disease activity made up 33.3%,and of all the 26 patients in the control group,the number of patients with disease activity accounted for 92.3%,P<0.05 the difference was statistically significant.In experimental group,the situation of 7cases was mild,1cases were moderate,no one was severe,in control group,the situation of 14 cases were mild,6cases were moderate and 4cases were severe.And the deterioration in situation of patients in control group was more obvious than that in the experimental group.Conclusion:To instruct the pregnancy of patients with SLE,pay attention to the selection of pregnancy timing and strengthen maternal and child care,rationally apply drugs can significantly reduce the occurrence of SLE and improve maternal and infant outcomes.

关 键 词：妊娠时机 系统性红斑狼疮 妊娠结局 

分 类 号：R714.259[医药卫生—妇产科学]