上海地区560例光斑贴试验结果分析  

Analysis of Photopatch Testing Results of 560 Cases in Shanghai District

作　　者：胡跃[1] 唐慧[1] 王朵勤[1] 盛友渔[1] 杨勤萍[1] 

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040

出　　处：《中国临床医学》2015年第5期667-669,共3页Chinese Journal of Clinical Medicine

基　　金：上海市科学技术委员会医学重点项目(12411951500)

摘　　要：目的:回顾分析2014年1月—12月皮肤科门诊进行的560例皮肤炎性疾病患者光斑贴试验结果,探讨接触性变应原和光接触性变应原在一些皮肤炎性疾病中的作用。方法:收集接受光斑贴试验检测的皮肤炎性疾病患者患者560例,根据国际接触性皮炎研究组(International Contact Dermatitis Research Group,ICDRG)的标准判读光斑贴试验结果,比较20种变应原的光接触性皮炎(photoallergic contact dermatitis,PACD)及接触性皮炎(allergic contact dermatitis,ACD)的阳性率。结果:560例患者中,PACD阳性378例(65.17%),ACD阳性342例(58.97%),PACD和ACD均阳性62例(10.69%)。PACD最常见的阳性变应原是氯丙嗪(56.81%)、硫柳汞(12.19%)、甲醛(7.89%),ACD最常见的阳性变应原是甲醛(22.04%)、重铬酸钾(21.14%)、氯丙嗪(14.70%)。PACD和ACD均阳性的变应原中最常见的是氯丙嗪(6.27%)、硫柳汞(2.33%)、硫酸镍(1.61%)。结论:光接触性变应原和接触性变应原可能与慢性光化性皮炎、面部皮炎、湿疹等炎症性皮肤病的发病有关。Objective：To explore the roles of contact allergens and photoallergens in the treatment of several inflammatory skin diseases by retrospectively analyzing the photopatch testing results of 560 patients from the Dermatology Department during January 2014 and December 2014.Methods：A total of 560 patients undergoting photopatch testing were collected.The positive rates of photoallergic contact dermatitis（PACD）,as well as those of allergic contact dermatitis（ACD）among the 20 types of allergens were compared by evaluating the photopatch testing results based on criteria from the International Contact Dermatitis Research Group（ICDRG）.Results：Among the 560 patients,there were 378 cases（65.17%）with PACD positive,342 cases（58.97%）with ACD positive,and 62 cases（10.69%）with both PACD-and ACD-positive.The most common allergens among PACD-positive patients were chlorpromazine（56.81%）,thiomersal（12.19%）,and formaldehyde（7.89%）,whereas the most common allergens among ACD-positive patients were formaldehyde（22.04%）,potassium dichromate（21.14%）,and chlorpromazine（14.70%）.Furthermore,the most common allergens among PACD-and ACD- positive patients were chlorpromazine（6.27%）,thiomersal（2.33%）,and nickel sulfate（1.61%）.Conclusions：Photoallergens and contact allergens may be related to the pathogenesis of inflammatory skin diseases such as chronic actinic dermatitis,facial dermatitis,and eczema.

关 键 词：光斑贴试验 光接触性皮炎 接触性皮炎 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]