围麻醉诱导期应用右美托咪定对血流动力学的影响  

Influence of dexmedetomidine applied in anesthesia induction period on hemodynamics

作　　者：韩园[1,2] 王聪[2] 孟文晴[2] 张月英[2] 

机构地区：[1]徐州医学院附属医院麻醉科,221000 [2]徐州医学院江苏省麻醉学重点实验室

出　　处：《中国实用医药》2015年第33期3-5,共3页China Practical Medicine

摘　　要：目的探讨围麻醉诱导期应用右美托咪定(DEX)对于血流动力学的影响。方法 50例拟行全凭静脉麻醉的普外科手术患者,按照随机原则分为诱导前给药组(B组,25例)和诱导后给药组(D组,25例),B组:麻醉开始前给予DEX(1 g/kg,输注时间10 min),D组:在麻醉维持期,给予DEX(1 g/kg,输注时间10 min)。观察两组患者给予DEX前(T0),注药后5 min(T1)和10 min(T2)时收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)和心率(HR)的变化。结果与T0时间点相比较,B组在T1和T2时间点SBP、DBP、MAP变化不明显,差异无统计学意义(P>0.05);与T0时间点比较,D组在T1和T2时间点SBP、MAP均显著升高,差异有统计学意义(P<0.05);D组MAP升高的发生率显著高于B组,差异有统计学意义(P<0.01);与T0时间点比较,B组和D组在T1和T2时间点的HR均显著下降,差异有统计学意义(P<0.05)。结论在麻醉诱导前,不给予麻醉药物时单纯应用DEX不影响患者MAP,但是在麻醉维持期使用DEX可显著升高患者MAP。Objective To investigate dexmedetomidine（DEX） applied in anesthesia induction period on hemodynamics. Methods A total of 50 patients undergoing general surgery and total intravenous anesthesia were randomly divided into pre-induction medication group（group B, 25 cases） and post-induction medication group（group D, 25 cases）. Group B received DEX before anesthesia（1 g/kg, infusion time as 10 min） and group D received DEX in anesthesia maintenance phase（1 g/kg, infusion time as 10 min）. Changes of systolic blood pressure（SBP）, diastolic blood pressure（DBP）, mean arterial pressure（MAP）, and heart rate（HR） in the two groups were observed before DEX administration（T0）, 5 min（T1） and 10 min（T2） after infusion. Results Comparing with T0, Group B had no statistically significant difference of SBP, DBP, MAP in T1 and T2（P〈0.05）. Group D had obviously higher SBP and MAP in T1 and T2 than in T0, and its difference had statistical significance（P〉0.05）. Group D had much higher incidence of increased MAP than group B, and the difference had statistical significance（P〈0.01）. Both group B and group D and obviously reduced HR in T1 and T2, comparing with that in T0. Their difference had statistical significance（P〈0.05）. Conclusion Before anesthesia induction, single administration of DEX without any other anesthesia medication has no influence on MAP in patients. Implement of DEX in anesthesia induction period will remarkably increase their MAP.

关 键 词：右美托咪定 血流动力学 麻醉诱导期 

分 类 号：R614[医药卫生—麻醉学]