中老年隐性脊柱裂患病率及其与膀胱过度活动症相关性的研究  

Morbidity of spina bifida occulta among middle-aged and elderly people and the relationship with overactive bladder

作　　者：吴军卫[1] 文建国[1] 邢玉荣[2] 牛建华[1] 谢佳丰 冯全得 尚小平[3] 李云龙[1] 冯锦锦[1] 翟荣群 

机构地区：[1]郑州大学第一附属医院泌尿外科尿动力中心河南省临床医学重点学科开放实验室,450052 [2]郑州大学第一附属医院体检中心,450052 [3]郑州大学第一附属医院病案统计室,450052

出　　处：《中华泌尿外科杂志》2015年第12期899-904,共6页Chinese Journal of Urology

基　　金：国家自然基金面上项目（81373869）;郑州大学优秀博士论文培育基金

摘　　要：目的 调查40岁以上中老年隐性脊柱裂（spina bifida occulta,SBO）的患病率及其与膀胱过度活动症（OAB）的相关性.方法 采用多层分级随机抽样、横断面调查的方法,选取郑州市7个社区的1 120名≥40岁的居民,于我院体检中心进行体检及抽样调查,填写SBO与排尿异常相关性调查问卷,行腰骶部数字化X线片（digital radiography,DR）检查.调查问卷包括个人基本信息、既往史、现病史,以及膀胱过度活动症症状评分（overactive bladder symptom score,OABSS）等.SBO及OAB患病率组间差异比较采用x2检验,OAB影响因素分析采用Logistic回归多因素分析法.结果 本研究有效样本量为1 061例,男471例,女590例.年龄40-100岁,平均（58.8±11.7）岁.160例诊断为SBO,男86例,女74例.SBO总患病率为15.1％（160/1 061）,男性SBO患病率为18.3％（86/471）,女性为12.5％（74/590）,男性显著高于女性（P＜0.05）.145例诊断为OAB,男62例,女83例.OABSS评分平均为（7.26±2.54）分.OAB总患病率为13.7％（145/1 061）,男性患病率为13.2％（62/471）,女性为14.1％（83/590）.Logistic回归分析结果表明SBO是OAB发病的的危险因素之一（OR =4.91,95％ CI 3.20 -7.53,P＜0.05）.结论 中老年SBO的患病率较高,SBO可能是中老年OAB发病的危险因素之一.Objective To investigate the morbidity of SBO among middle-aged and elderly people and its relationship with OAB.Methods A cross-sectional and community-based survey was carried out among residents who were 40 years old or above in 7 communities （randomly selected） in Zhengzhou.All cases （1 120 residents） underwent lumbosacral digital radiography （DR）examination and were asked to complete a questionnaire which contained basic information,past history,present history and OAB symptom score （OABSS）.Chi-square test and Logistic regression were used for data analysis.P 〈 0.05 was considered to be statistical significance.Results A total of 1 061 subjects （58.8 ± 11.7 years old） consisting of 471 males （44.4%） and 590 females （55.6%） were qualified for the final statistical analysis..The morbidity of SBO among 40 years old or above people was 15.1% （160/1 061） in total,while 18.3% （86/471） and 12.5% （74/590） in males and females respectively.The morbidity of SBO is significantly higher in males than in females（P 〈0.05）.145 cases presented with OAB,including 62 males and 83 females.The average value of the patients＇ OABSS was 7.26 ± 2.54.The morbidity of OAB was 13.7% in total,while 13.2% （62/471） in males,and 14.1% （83/590） in females.Besides,the result of logistic regression showed that SBO was the risk factor for OAB （P 〈 0.001）,the OR vable was 4.91,and the95%CI was 3.20 -7.53 （P 〈0.05）.Conclusions The morbidity of SBO among middle-aged and elderly people is great,and the SBO could be a pathogenetic risk factor for OAB among elderly people.

关 键 词：隐性脊柱裂 患病率 膀胱过度活动症 中老年人 

分 类 号：R681.5[医药卫生—骨科学] R694[医药卫生—外科学]