急性心肌梗死患者hs-CRP与AIP,HbA1c,cTnI相关性分析及临床意义  

Correlation Analysis and Clinical Significance of AIP,HbA1c,cTnI and hs-CRP in Patients with Acute Myocardial Infarction

作　　者：孙阿林 王健[2] 谢地成 周鹏[1] 李晓东[1] 高安路 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊市人民医院心内科

出　　处：《潍坊医学院学报》2015年第6期426-429,共4页Acta Academiae Medicinae Weifang

摘　　要：目的探讨急性心肌梗死患者早期超敏C反应蛋白(hs-CRP)与致动脉硬化指数(AIP)、糖化血红蛋白(HbA1c)肌钙蛋白Ⅰ(cTnI)的相关性并评价其临床意义。方法选取135例急性心肌梗死患者,检测血浆hs-CRP,HbA1c,CHO,TG,HDL-C,LDL-C,cTnI等指标,计算AIP;选取123例经冠脉造影证实无冠心病患者作为对照组。测定两组患者相关指标的相关性及临床意义。结果心肌梗死组患者hs-CRP,AIP,HbA1c,cTnI水平均高于对照组(P<0.05或P<0.01),且均是心肌梗死的独立危险因素(P<0.05或P<0.01);两组患者hsCRP水平与AIP,HbA1 c无相关性(P>0.05),而心肌梗死组患者hs-CRP与cTnI成正相关(r=0.549,P=0.000);对于急性心肌梗死的诊断价值判定cTnI具有较高的诊断价值(AUC=0.928>0.9),而AIP,HbA1c则诊断价值较低(AUC<0.7)。结论 hs-CRP与急性心肌梗死的发生密切相关,且可能是独立于血糖、血脂以外的独立危险因素;同cTnI,hs-CRP对急性心肌梗死的诊断及病情评估有重要的临床意义,可纳入常规检测指标。Objective To explore the correlation and clinical significance of AIP,HbA1c,cTnI and hs-CRP in patients with a-cute myocardial infarction.Methods 135 cases of patients with acute myocardial infarction were enrolled in the experiment,plasma hs-CRP, HbA1c,CHO,TG,HDL-C,LDL-C,cTnI and other indicators were detected,then calculated to arterial stiffness index（AIP）;123 cases of pa-tients without coronary heart disease confirmed by coronary angiography（ CAG） were selected as control group.To determine the correlation of relevant indicators between the two groups and to assess clinical significance.Results The levels of AIP,hs-CRP,cTnI and HbA1c were higher in AMI group than that in control group（P〈0.05 or P〈0.01）,and were all independent risk factors for myocardial infarction（P〈0. 05 or P〈0.01）.There was no correlation between the two groups of patients with hs-CRP and AlP,HbA1c levels（P〉0.05）,but there was positive correlation between hs-CRP and cTnI in patients with acute myocardial infarction（r=0.549,P=0.000）;cTnI had a high diagnostic value（AUC=0.928〉0.9） for the diagnosis of acute myocardial infarction,while the diagnostic value of AIP and HbA1c were lower（AUC〈0.7）.Conclusion hs-CRP is closely related to the occurrence of acute myocardial infarction,and may be independent of the independent risk factors of blood sugar and blood fat;As well as cTnI,hs-CRP also has important clinical significance in the diagnosis and assessment of a-cute myocardial infarction,and can be used as a routine examination index.

关 键 词：超敏C反应蛋白 肌钙蛋白I 致动脉硬化指数 糖化血红蛋白 心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]