丹蛭降糖胶囊联合阿司匹林抗栓作用的临床观察  

Capsules of Compound Cortex Moutan & Leech Combined Aspirin Antithrombotic Effect of Clinical Observation

作　　者：何佳[1] 胡业彬[1] 杜卫甫[1] 张叶祥[1] 方朝晖[1] 

机构地区：[1]安徽中医药大学第一附属医院,合肥230031

出　　处：《浙江中医药大学学报》2015年第10期740-744,共5页Journal of Zhejiang Chinese Medical University

基　　金：国家自然科学基金面上项目(81072780);国家中医药管理局国家中医药临床研究基地建设项目(20081211);国家科技部重大项目(2010ZX09102);中国临床试验注册中心注册课题(ChiCTR-OCH-12002780)~~

摘　　要：[目的]探讨阿司匹林联合丹蛭降糖胶囊对"气阴两虚夹瘀"型高血压及高血压合并2型糖尿病患者血小板聚集率(platelet aggregation rate,PAG)和凝血功能的影响。[方法]按照就诊顺序及病史选取50例"气阴两虚夹瘀"型单纯高血压患者为A组,50例"气阴两虚夹瘀"型高血压合并2型糖尿病患者为B组,均已常规服用阿司匹林(100 mg,1次/d)>2周,入选后两组均加用丹蛭降糖胶囊3粒,3次/d,连服4周。于治疗前后检测血小板计数(blood platelet count,BPC)、PAG、凝血全套等。[结果]1血小板计数:两组治疗前后血小板计数均无明显差异(P>0.05)。治疗前后两组间的血小板计数均无明显差异(P>0.05)。2PAG:两组患者治疗后花生四烯酸(arachidonic acid,AA)诱导的PAG均明显低于治疗前(P<0.05)。两组间比较,治疗前B组PAG较A组高,差异有统计学意义(P<0.05);治疗后两组PAG的差异无统计学意义(P>0.05)。3凝血功能:两组患者治疗后D-二聚体、血浆纤维蛋白原(plasma fibrinogen,FIB)及部分凝血活酶时间(activated partial thromboplastin time,APTT)较治疗前均有明显改善(P<0.05);凝血酶时间(thrombin time,TT)及凝血酶原时间(prothrombin time,PT)两组治疗前后均无明显改善(P>0.05)。两组间比较,治疗前两组D-二聚体及凝血四项无显著差异(P>0.05);治疗后B组FIB下降值较A组明显(P<0.05),APTT及D-二聚体下降值两组无明显差异(P>0.05)。[结论]较单独应用阿司匹林治疗,联合丹蛭降糖胶囊可以进一步降低两组患者PAG水平、改善凝血功能,对于合并糖尿病患者在降低血浆D-二聚体、FIB及APTT水平更明显。[Objective] Study effect of the aspirin joined with Dan vermiculite hypoglycemic capsule on platelet aggregation rate and blood coagulation function in patients with hypertension and hypertension combined with type 2 diabetes mellitus. [Methods] According to the history of medical order,select 50 patients of group A, patients with high blood pressure so as to 50 patients with hypertension combined with type 2 diabetes mellitus as group B,the doctor of traditional Chinese medicine syndrome differentiation is ＂qi and Yin deficiency clip stasis＂ type, have regular aspirin（100 mg, 1/d） 2 weeks,to be included in the two groups after all with Dan vermiculite hypoglycemic capsule 3 grains, three times a day, take 4 weeks, in the detection of platelet count（BPC） before and after the treatment, platelet aggregation rate（PAG）, coagulation full set, etc. [Results] 1. The platelet count, platelet count before and after treatment, two groups had no significant difference（P〉0.05）.Platelet count between the two groups before and after treatment had no obvious difference（P〉0.05）.2. Platelet aggregation rate（PAG）：two groups of patients after treatment the PAG induced by arachidonic acid（AA） were significantly lower than before treatment（P〉0.05）.Comparison between the two groups, the treatment group A was lower than those of group B, PAG before was statistically significant（P〉0.05）;In the two groups after treatment the difference of PAG had no statistical significance（ P〉0.05）.3. The blood coagulation function： two groups after treatment in patients with D-dimer, FIB and APTT compared with that before treatment were significantly improved（ P0.05）;TT and PT before and after treatment were obviously improved in the two groups（ P0.05）. Comparison between the two groups, the treatment in the first group D-dimer and blood coagulation had no significant difference（P〉0.05）; Group B after treatment FIB values compared with group A decreased significantly（P0.05）, A

关 键 词：丹蛭降糖胶囊 阿司匹林 高血压 2型糖尿病 PAG 凝血功能 气阴两虚 血瘀 

分 类 号：R587[医药卫生—内分泌]