心房颤动住院患者抗栓治疗分析  

An investigation about the antithrombotic therapy in the hospitalized patients with atrial fibrillation

作　　者：白颖[1] 王家伟[1] 

机构地区：[1]首都医科大学附属北京同仁医院药学部,北京市100730

出　　处：《中国基层医药》2015年第24期3732-3735,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：分析住院心房颤动（房颤）患者抗栓治疗现状，从而为临床合理用药提供参考。方法回顾性分析首都医科大学附属北京同仁医院2014年7～9月住院房颤患者169例的临床资料，对血栓风险分层、房颤类型、药物选择、合并用药以及不良反应情况进行分析。结果169例房颤患者中，瓣膜病房颤构成比14．20％（24／169），非瓣膜病房颤构成比85．80％（145／169），年龄≥60岁及以上房颤患者比例为84．62％（143／169）。抗凝治疗药物应用最多为华法林，所占比例94．87％（74／78），华法林平均日剂量为（2．514±0．842）mg，INR 在2．0～3．0之间的病例约占41．89％（31／74）。不良反应发生率为2．56％（2／78）。结论目前房颤患者抗栓治疗不足，临床药师需分析影响房颤抗凝治疗的因素以促进合理用药。Objective To analyze the conditions of antithrombotic therapy in patients with atrial fibrillation （AF）and provide reference for clinical rational use of drugs.Methods The clinical data of 1 69 hospitalized patients with AF from July 201 4 to September 201 4 in Beijing Tongren Hospital affiliated to Capital Medical University were retrospectively analyzed.The risk stratification for thromboembolism,types of AF,drug selection,drug combination and adverse reactions were analyzed.Results In 1 69 patients with AF,the proportion of valvular AF was 1 4.20%（24 /1 69）and non -valvular AF was 85.80%（1 45 /1 69）,the patients with AF aged over 60 years old accounted for 84.62%.In the antithrombotic therapy,warfarin accounted for 94.87% （74 /78）,the average daily dosage was （2.51 4 ±0.842）mg,the cases with INR between 2.0 to 3.0 accounted for 41 .89%（31 /74）.The incidence rate of adverse reactions was 2.56%（2 /78）.Conclusion The antithrombotic therapy is obviously insufficient,the clinical pharmacists should analyze the factors which influence the treatment and promote the rational use of antithrombotic therapy in AF patients.

关 键 词：心房颤动 血栓形成倾向 治疗学 

分 类 号：R541.75[医药卫生—心血管疾病]