慢性高原病及高原健康人血清干细胞因子水平变化的研究  

Expression of Stem Cell Factor in Serum of Patients with Chronic Mountain Sickness and Healthy People in High Altitude

作　　者：苏娟[1] 柴克霞[1] 李占全[1] 崔森[1] 冀林华[1] 陈媛清[1] 杨洁[1] 秦雅婧[1] 

机构地区：[1]青海大学附属医院血液风湿科,810001

出　　处：《高原医学杂志》2015年第3期10-13,共4页Journal of High Altitude Medicine

基　　金：青海省国际科技合作项目(2015-HZ-810)

摘　　要：目的:研究慢性高原病患者及高原健康人群血清干细胞因子水平,探讨干细胞因子在慢性缺氧条件下的病理及生理意义。方法:采用双抗体夹心酶联免疫吸附法测定20例慢性高原病患者(慢性高原病组),22例世居青海省玉树市健康藏族(世居组),24例移居玉树市汉族组(移居组),24例世居青海西宁市汉族健康人(对照组)血清干细胞因子水平并进行比较,分析干细胞因子与各组实验室指标的相关性。结果:1各组血清干细胞因子含量有显著性差异(F=2.281,P<0.05),其中慢性高原病组(843.4±159.3)pg/m L与世居藏族组(975.9±120.0)pg/m L比较差异有统计学意义(P<0.05),世居藏族与对照组比较,差异有统计学意义(975.9±120.0)pg/m L vs(865.0±148.4)pg/m L,P<0.05;2各组血清干细胞因子水平与Hb和SaO_2之间均无相关性。结论:干细胞因子可能在高原适应的机制中发挥重要作用,加强SCF在高原低氧环境下的研究,可能为慢性高原病的防治提供新的研究方向。Objective： To investigate the role of stem cell factor（ SCF） in serum of patients with chronic mountain sickness（ CMS） and healthy people in high altitude. Methods： Enzyme- linked immunosorbent assay（ ELISA） was used to determine the levels of serum stimulating colony factor,（ SCF） in chronic mountain sickness,（ CMS）（ n = 20）; native Tibetan high altitude（ n = 22）,immigrant Han native（ n = 24）,as healthy controls（ n = 24）. Variance and Pearson＇s correlation analysis were used for statistical analysis. Results： ①The concentrations of serum SCF were significantly different in the four groups（ F = 2. 281,P〈0. 01）. The expression levels of serum SCF were higher in native Tibetan high altitude compared with CMS,（ 975. 9 ± 120. 0） pg / m L vs（ 843. 4 ± 159. 3） pg /m L（ P〈0. 05） and SCF were higher in native Tibetan high altitude compared with healthy controls,（ 975. 9 ± 120. 0） pg / m L vs（ 865. 0 ± 148. 4） pg / m L（ P〈0. 05）; ②There were no significant correlation between the expressions of SCF and hemoglobin,arterial oxygen saturation in four groups（ P〉0. 05）. Conclusion： Altered expression of SCF may be involved in the the mechanisms of high altitude adaptation.

关 键 词：慢性高原病 干细胞因子 高原适应 藏族 

分 类 号：R594.3[医药卫生—内科学]