遵义地区多发性硬化患者血清BDV-CIC及抗体的检测  

Detection of the BDV specific CIC in plasma of patients with multiple sclerosis of Zunyi regions

作　　者：刘海军[1] 邬小燕[2] 田永攀[1] 徐平[1] 

机构地区：[1]遵义医学院附属医院神经内科,贵州遵义563000 [2]遵义医学院附属医院新生儿科,贵州遵义563000

出　　处：《中国生化药物杂志》2015年第9期64-66,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：国家自然科学基金(31160210);贵州省科学技术基金(黔科合J字LKZ[2011]13号)

摘　　要：目的探讨博尔纳病病毒(Borna disease virus,BDV)感染与遵义地区多发性硬化(multiple sclerosis,MS)患者的相关性。方法运用新型的三联ELISA测循环免疫复合物、抗体的方法,检测7例MS患者及93例健康对照组血清中BDV特异性循环免疫复合物(circulating immune complex,CIC)及抗体。结果 7例MS中有2例CIC及抗体均为阳性,阳性率为28.57%(2/7);93例对照组中CIC阳性7人,阳性率为7.53%(7/93),抗体阳性5例,阳性率为5.38%(5/93);多发性硬化组检出率高于健康对照对照组,但2组比较无统计学意义。结论遵义地区存在着BDV的感染,BDV感染与多发性硬化不一定相关。Objective To study the correlation with the infectious situation of Borna disease with the multiple sclerosisof Zunyi region.Methods Established method of the specific CIC and an antibody of Borna were used to detect the PBMC of 7cases of patients with multiple sclerosis and93 cases of control group. Results In the collected 7 cases of PBMC in patients with multiple sclerosis,detected 2 positive samples of the specific CIC and antibody of Borna with a positive rate of 28. 57%（ 2 /7）. Meanwhile,positive plasma samples were also detected in healthy control group,and the positive rate was 7. 53%（ 7 /93）,The antibody positive rate of control group was also 5. 38%（ 5 /93）. But between the two groups,the difference was no statistically significant. Conclusion Results indicate that the possibility of BDV infection is presented in Zunyi regions. BDV infection is not necessarily associated with multiple sclerosis.

关 键 词：博尔纳病病毒 循环免疫复合物 酶联免疫吸附试验 多发性硬化 

分 类 号：R751[医药卫生—皮肤病学与性病学]