地佐辛与芬太尼对乳腺癌患者手术后免疫状况与血清炎性因子影响的对比研究  

Comparison of dezocine and fentanyl on immune status and serum levels of inflammatory cytokines of patients with breast cancer after surgery

作　　者：李文星[1] 李锦成[1] 

机构地区：[1]天津医科大学肿瘤医院国家肿瘤临床医学研究中心天津市"肿瘤防治"重点实验室麻醉科,天津市300060

出　　处：《中国生化药物杂志》2015年第9期76-78,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨不同镇痛方案对乳腺癌患者手术后免疫状况与血清炎性因子的影响。方法收集天津医科大学肿瘤医院救治欲行乳腺根治术的乳腺癌患者60例。随机将所选患者分为实验组及对照组。围手术期实验组与对照组患者分别使用地佐辛与芬太尼镇痛,对2组患者的免疫状况及血清炎性因子进行分析与对比。结果术毕及术后1 d实验组患者的外周T淋巴细胞亚群(CD3+、CD4+的水平及CD4+/CD8+比值)与NK细胞的水平均明显高于对照组(P<0.05);术毕及术后1d实验组患者血清中的抗炎因子明显高于对照组(P<0.05);术毕及术后1d实验组患者血清中的促炎因子明显低对照组(P<0.05)。结论地佐辛能明显改善手术后乳腺癌患者血清中的炎性因子,调节患者的免疫状况。Objective To discuss comparison of different analgesic solution to the immune status and serum levels of inflammatory cytokines of the patients with breast cancer after surgery. Methods The patients of experimental group and control group were given Dizocine and fentanyl to analgesic respectively perioperative experimental. Then analysis and comparison the immune status and serum levels of the two groups. Results The T lymphocyte subsets（ The level of CD3＋、CD4＋and the ratio CD4＋/ CD8＋） and the level fo NK cells of the exprimental group patients intraoperative and postoperative 1 d were significantly higer than the control group. The anti-inflammatory factor in the serum of the experimental group patients intraoperative and postoperative 1d was significantly higer than the control group. The proinflammatory factor in the serum of the experimental group patients intraoperative and postoperative 1 d was significantly lower than the control group. Conclusion Dizocine can significantly improve the serum inflammatory factors of the patients with brest cancer after surgery,and can adjust the patient＇s immune status.

关 键 词：镇痛方案 乳腺癌 免疫状况 炎性因子 

分 类 号：R614[医药卫生—麻醉学]