比较替格瑞洛与氯吡格雷对老年患者支架术后出血的影响  

Comparison of ticagrelor versus clopidogrel in effect of bleeding in elderly patients after stenting

作　　者：林开敏[1] 吴雅芳[1] 谢强[1] 

机构地区：[1]厦门大学附属第一医院心内科,福建厦门361003

出　　处：《中国生化药物杂志》2015年第9期152-154,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨比较替格瑞洛与氯吡格雷对老年患者支架术后出血的影响。方法收集厦门大学附属第一医院收治的急性冠脉综合征行支架置入手术的老年患者48例,根据用药不同分为氯吡格雷组和替格瑞洛组,每组各24例,分别给予相应的药物治疗,治疗结束后,对所有患者的血小板抑制率、心血管事件及出血事件发生情况进行观察。结果治疗后,与氯吡格雷组比较,替格瑞洛组患者血小板抑制率较高(P<0.05)、心血管事件的发生率较低(4.16%vs.25.00%;P<0.05)、出血事件的发生率差异无统计学意义(4.16%vs.8.32%)。结论在支架术后的老年患者中,与氯吡格雷比较,替格瑞洛能够更好地抑制血小板聚集,防止心血管事件发生,且不会增加出血风险。Objective To compare effect of ticagrelor and clopidogrel on bleeding in elderly patients after stenting. Methods 48 elderly patients after stenting who were diagnosed with acute coronary syndrome in the hospital were collected. All patients were divided into clopidogrel group and ticagrelor group according to different therapy,24 cases in each group,and were given corresponding drug treatment in each group. After treatment,the platelet inhibition rate,cardiovascular events and bleeding events were observed. Results After treatment,compared with clopidogrel group,the platelet inhibition rate was higher in ticagrelor group（ P〈0. 05）,the incidence of cardiovascular events was lower in ticagrelor group（ 4. 16% vs. 25. 00%; P〈0. 05）,but there was no obvious difference in incidence of bleeding events of ticagrelor group（ 4. 16% vs. 8. 32%）. Conclusion In elderly patients after stent implantation,ticagrelor could inhibit platelet aggregation better than clopidogrel,prevent the occurrence of cardiovascular events,and would not increase the risk of bleeding.

关 键 词：替格瑞洛 氯吡格雷 支架术后 出血 

分 类 号：R541[医药卫生—心血管疾病]