红细胞力学性能对血管狭窄处血小板聚集影响的数值分析  

Numerical study of the effect of erythrocyte mechanical properties on the aggregation of platelets

作　　者：余艺[1] 许菁[1] 王骁龙 刘筠乔[1,2] 龚晓波[1,2] 

机构地区：[1]上海交通大学工程力学系,上海200240 [2]上海交通大学水动力学教育部重点实验室,上海200240

出　　处：《水动力学研究与进展（A辑）》2015年第6期624-631,共8页Chinese Journal of Hydrodynamics

摘　　要：该文采用浸入式边界法(IBM),以日本理化研究所Sugiyama[1,2]的程序为平台,模拟了多个血小板在血管狭窄处的聚集过程。采用厚度由忽略不计的超弹性膜包裹的黏性液滴模拟细胞。数值模拟结果表明:血小板在聚集过程中同时受到了粘附力、聚集力和流场力的影响;红细胞体积比和硬度的增加,都会增强血小板在狭窄血管中的聚集。The effect of erythrocyte mechanical properties on the aggregation of the platelets was numerically studied with the immersed boundary method. The program written by Sugiyama in RIKEN was applied to the simulation work. Cells were modeled as viscous-fluid-filled capsules surrounded by a hyper-elastic membrane with negligible thickness. The numerical results show that with the increase in hematocrit, the aggregation of platelets is enhanced. The aggregation of platelets is also enhanced by increasing the stiffness of erythrocytes.

关 键 词：血流动力学 流体结构耦合 浸入式边界法 血小板聚集 

分 类 号：O357[理学—流体力学]