Angiostatin对转移性肿瘤血液灌注影响的三维数值模拟  

3D numerical simulation of the inhibitory effect of angiostatin on blood perfusion in the metastatic tumor

作　　者：陈楠心 赵改平[1] 宋燕美 王晨曦[1] 柏磊磊 陈二云[2] 俞晓立[3] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海理工大学能源与动力工程学院,上海200093 [3]复旦大学附属肿瘤医院,上海200032

出　　处：《水动力学研究与进展（A辑）》2015年第6期716-720,共5页Chinese Journal of Hydrodynamics

基　　金：国家自然科学基金(11502146);上海市自然科学基金(15ZR1429600);上海市科委科研计划项目(13DZ2260900)~~

摘　　要：该文基于抗血管生成因子Angiostatin作用下转移性肿瘤微血管网生成和血液灌注的三维数值模拟,研究抗血管生成因子Angiostatin对转移性肿瘤血液灌注及微环境变化的影响。模拟结果显示Angiostatin通过抑制转移性肿瘤内外微血管网的生长速率、分叉和融合等特征,进一步改善转移性肿瘤内血液灌注的特性,从而增加微血管内外物质交换的能力,可有效地降低肿瘤内药物输运的难度,为临床抗血管生成治疗肿瘤提供有益信息。Metastatic tumor angiogenesis and blood perfusion based on 3D numerical simulation response to angiostatin＇s inhibitory effect are investigated. Simulation results show that angiostatin can inhibit the growth of microvascular network, and decrease the branching, anastomosis and proliferation of capillary sprouts in metastatic tumor. Furthermore, angiostatin can improve the capacity for blood perfusion and material exchange within the metastatic tumor microenvironment. Hence, angiostatin can increase convective flow out of the vasculature and result in reducing the difficulty of drug delivery within the metastatic tumor. These researches may provide some theoretical references and foundation understandings for further clinical anti-angiogenic cancer therapy.

关 键 词：ANGIOSTATIN 转移性肿瘤 血液灌注 抑制效应 三维数值模拟 

分 类 号：R318.01[医药卫生—生物医学工程] TB115[医药卫生—基础医学]