慢性丙型肝炎患者治疗依从性及影响因素的研究  

The level and influence factors of treatment compliance among patients with chronic hepatitis C

作　　者：叶云[1] 郭琴芳[1] 谭友文[1] 

机构地区：[1]江苏大学附属镇江三院肝病科,江苏省镇江市212000

出　　处：《中华护理教育》2015年第12期885-888,共4页Chinese Journal of Nursing Education

基　　金：江苏省预防医学科研课题(Y2012016)

摘　　要：目的了解慢性丙型肝炎患者接受干扰素联合利巴韦林治疗的依从性及影响因素。方法分析2010年1月至2012年12月的306例住院治疗的慢性丙型肝炎患者的相关资料,包括一般资料、病史资料以及慢性丙型肝炎知识问卷。结果 306例患者中完成规范抗病毒治疗的104例,因干扰素不良反应不建议继续治疗的34例,未经医生同意不完成规范抗病毒治疗的168例。Logistic回归分析显示男性(OR=3.845,P=0.004)、费用子女承担(OR=4.264,P=0.002)、对不良反应耐受程度高(OR=3.436,P=0.013)以及丙型肝炎知识知晓程度好(OR=19.537,P<0.001)是慢性丙型肝炎患者接受干扰素联合利巴韦林治疗依从性的影响因素。结论慢性丙型肝炎患者接受干扰素治疗依从性较差,建议加强健康教育,积极针对药物不良反应进行干预,以期提高慢性丙型肝炎患者接受干扰素联合利巴韦林治疗的依从性。Objective To investigate the level and influence factors of compliance with interferon and ribavirin antiviral treatment in chronic hepatitis C patients. Methods Totally 306 chronic hepatitis C patients were investigated using a self-designed questionnaire about demographic data,disease-related data and hepatitis C knowledge. Results Follow-up data were collected from 306 cases,including 104 cases with good compliance,34 cases who gave up interferon treatment due to severe adverse drug reactions,and 168 cases with poor compliance.Logistic regression analysis showed that male patients（OR=3.845,P=0.004）,patients whose medical expenses were paid by children（OR=4.264,P=0.002）,patients with higher tolerance with adverse drug reactions（OR=3.436,P=0.013）,and patients with higher level of diseases related knowledge（OR=19.537,P0.001） were significant influence factors of treatment compliance.Conclusion Chronic hepatitis C patients have poor compliance with interferon and ribavirin antiviral treatment. It is suggested to strengthen health education and make efforts to reduce adverse drug reactions in order to improve patient compliance.

关 键 词：丙型肝炎 慢性 病人依从 抗病毒药 

分 类 号：R512.63[医药卫生—内科学]