利拉鲁肽治疗初诊断2型糖尿病患者血清miR-375的表达及胰岛功能的相关分析  

Expression of serum miR-375 and islet function of newly diagnosed type 2 diabetic patients with liraglutide treatment

作　　者：胥娟[1] 王尧[2] 唐伟[1] 朱琳[1] 高远[1] 

机构地区：[1]东南大学医学院附属江阴医院内分泌科,江苏江阴214400 [2]东南大学附属中大医院内分泌科,江苏南京210009

出　　处：《南京医科大学学报（自然科学版）》2015年第11期1590-1593,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81370920)

摘　　要：目的：探讨利拉鲁肽治疗初诊断2型糖尿病患者后血清mi R-375表达水平的变化,并分析其与胰岛素抵抗和胰岛β细胞功能变化的相关性。方法：30例初诊2型糖尿病受试者使用利拉鲁肽治疗12周,分别测定治疗前后患者的口服葡萄糖耐量试验（oral glucose tolerance test,OGTT）、胰岛素、C肽、糖化血红蛋白（Hb A1c）、体重、腰围、血压和血清mi R-375表达水平。采用配对t检验及Wilcoxon配对符号秩检验进行数据分析。结果：利拉鲁肽治疗前后,患者血清中的mi R-375表达量和Hb A1c显著降低（P〈0.05）,胰岛素0-30 min曲线下面积、胰岛素0~120 min曲线下面积明显增加（P〈0.05）。结论：利拉鲁肽治疗初诊断2型糖尿病后,胰岛β细胞功能的改善可能与血清中mi R-375表达下调有关。Objective：To explore mi R-375 expression level changes of newly diagnosed patients with type 2 diabetic after liraglutide treatment, and analyze the relationship between insulin resistance and functional changes in pancreatic islet β cells.Methods： A total of 30 patients of newly diagnosed type 2 diabetes were selected to examine the oral glucose tolerance test（OGTT）, insulin, C peptide, haemoglobin A1C（Hb A1c）, weight, waist circumference, blood pressure and mi R-375 expression level changes in serum before and after 12 weeks of liraglutide treatment. Data analysis was performed using paired t test and Wilcoxon signed rank test. Results： Mi R-375 expression and Hb A1 c were decreased after liraglutide treatment（P〈0.05）. Areas under the curve of blood glucose 0-30 min and 0-120 min were significant increased（P〈0.05）. Conclusion： After liraglutide treatment, insulin resistance and functional changes in pancreatic islet β cells of diabetics were improved, it may be related to the decrease of mi R-375 expression level in serum.

关 键 词：miRNA-375 糖尿病 胰岛Β细胞功能 

分 类 号：R587.1[医药卫生—内分泌]