清喉利咽颗粒联合养阴清肺糖浆对氨水及SO_2诱导小鼠咳嗽的影响作用  

The Effect of Qinghou Liyan Granules and Yangyin Qingfei Syrup on the Cough Caused by Ammonia Water and SO_2 in Mice

作　　者：吴健广 郭思佳[2] 郝正华[3] 刘伟[2] 刘恩顺[2] 封继宏[2] 

机构地区：[1]天津市东丽区中医医院,天津300300 [2]天津中医药大学第二附属医院,天津300150 [3]天津中医药大学,天津300193

出　　处：《世界中医药》2015年第11期1760-1763,共4页World Chinese Medicine

摘　　要：目的:观察清喉利咽颗粒、养阴清肺糖浆及二药联合应用对氨水及SO_2诱导小鼠咳嗽的止咳作用。方法:分别将健康清洁级雄性昆明小鼠60只随机等分为对照组、养阴清肺糖浆组、清喉利咽颗粒组、清喉利咽颗粒联合养阴清肺糖浆组、孟鲁司特钠组、甘草合剂组。对照组给予生理盐水灌胃,其余各组给予相应药物治疗,1次/d,连续7 d,末次给药1 h后将小鼠放入YLS-8A型多功能诱咳引喘仪中,分别采用氨水及SO_2刺激小鼠咳嗽,自动记录小鼠咳嗽潜伏时间及3 min内咳嗽次数。结果:与对照组比较,养阴清肺糖浆、清喉利咽颗粒组及二药联合应用组能明显延长氨水和SO_2诱导小鼠咳嗽的潜伏时间(P<0.05),并减少其咳嗽次数(P<0.05);与对照组、养阴清肺糖浆组、甘草合剂组和孟鲁司特钠组比较,二药联合应用组在延长氨水和SO_2诱咳小鼠咳嗽潜伏时间及减少咳嗽次数方面作用更为显著(P<0.05);与清喉利咽颗粒组比较,二药联合应用组仅在延长氨水和SO_2诱咳小鼠咳嗽潜伏时间方面效果更好(P<0.05)。结论:清喉利咽颗粒、养阴清肺糖浆均具有良好的止咳作用,二药联合应用具有协同作用,能够延缓咳嗽的发生,增强止咳作用。Objective：To observe the effects of Qinghou Liyan granules,Yangyin Qingfei syrup and Qinghou Liyan granules combined with Yangyin Qingfei syrup in the treatment of cough in mice caused by ammonia water and sulphur dioxide gas.Methods;Sixty of healthy,clean and male mice were randomly divided into six groups：control group,Yangyin Qingfei Granules group,Qinghou Liyan syrup group,Yangyin Qingfei granule combined with Qinghou Liyan group,Montelukast group and Mixture Glycyrrhiza group.The control group were given water,and the other groups were given drugs.The treatment term lasted for seven days,and drugs were given everyday.Around an hour after giving the drug,mice were placed in YLS-8A device and ammonia water and sulphur dioxide gas were used to induce cough in mice respectively.Recorded were potential cough and the times of cough in three minutes.Results：Compared with the control group,other groups have more obvious effects on extending the incubation period of cough in mice and reducing the times of cough in mice caused by ammonia water and sulfur dioxide gas（P〈0.05;Compared with the control group,Yangyin Qingfei syrup group,Gancao mixture group and Montelukast Sodium Tablets group,Qinghouliyan granules combined with Yangyinqingfei syrup group has a better effect on extending the incubation period of cough in mice and reducing the times of cough in mice caused by ammonia water and sulfur dioxide gas（P〈0.05;Compared with Qinghou Liyan granules group,Qinghouliyan granules combined with Yangyinqingfei syrup group has a larger effect on extending the incubation period of cough in mice caused by ammonia water and sulfur dioxide gas（P〈0.05）.Conclusion：Both Qinghou Liyan granules and Yangyin Qingfei syrup have a effect on inhibiting cough.And Qinghou Liyan granules combined with Yangyin Qingfei syrup can enhance the effects of inhibiting cough and extending the incubation period of cough.

关 键 词：清喉利咽颗粒 养阴清肺糖浆 咳嗽 

分 类 号：R285.5[医药卫生—中药学]