脑络欣通颗粒对脑梗死急性期气虚血瘀证抗氧化低密度脂蛋白抗体和C反应蛋白的影响  

Effect of Naoluo Xintong particle on o LAB and CRP in cases with Qi deficiency and blood stasis in the stage of acute cerebral infarction

作　　者：陈城 鲁德甫 杨文明[2] 

机构地区：[1]安徽省妇幼保健院,安徽合肥230011 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中医药临床杂志》2015年第11期1580-1583,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：国家卫计委临床重点专科项目(NO:2100202);国家中医重点学科(NO:201232);国家科技部"十二五"支撑计划(NO:2012BAI26B02);安徽省科技攻关项目(NO:11010402167)

摘　　要：目的:观察脑络欣通颗粒对抗氧化低密度脂蛋白抗体(o LAB)和C反应蛋白(CRP)的影响,评价脑络欣通颗粒治疗缺血性中风(脑梗死)急性期气虚血瘀证的临床疗效。方法:将符合纳入病例标准的90例缺血性中风(脑梗死)急性期气虚血瘀证患者随机分为脑络欣通组,通心络组,常规组,常规组给予西医神经内科常规处理,通心络组在常规治疗基础上给予通心络胶囊,脑络欣通组在常规治疗基础上加用脑络欣通颗粒。观察患者治疗前,治疗后7天,14天3个不同时间点的神经功能缺损程度评分,日常生活活动能力评分,中医证候评分,抗氧化低密度脂蛋白抗体(o LAB)和C-反应蛋白(CRP),检测观察指标数值的变化,评价3组的临床疗效。结果:通心络组和常规组各脱落2例患者。3组均有变化,常规组虽有变化,但无统意义计学,与常规组相比,通心络组和脑络欣通组均有明显的改变(P<0.05或P<0.01),脑络欣通组又明显优于通心络组(P<0.05),说明脑络欣通颗粒可以更好的改善以上指标。结论:脑络欣通颗粒对脑梗死急性期气虚血瘀证患者可明显降低o LAB和CRP水平,且优于通心络胶囊。Objective：To observe Effect of Naoluo Xintong particle on o LAB and CRP in cases with Qi deficiency and blood stasis in the period of Acute cerebral infarction and evaluate the clinical effect of Naoluo Xintong particle. Methods： 90 patients were randomly divided into three groups including Naoluo Xintong particle group, Tong Xinluo group and control group. The control group was given conventional symptomatic treatment, Tong Xinluo group on the basis of routine treatment given Tong Xinluo capsule, Naoluo Xintong particle group on the basis of conventional therapy plus Naoluo Xintong particle. To observe index values change such as o LAB, CRP, NFDS, activities of daily living evaluation and TCM syndrome evaluation on the day of pre-treatment, 7 days and 14 days after the treatment. Results： Tong Xinluo group and Naoluo Xintong particle o LAB, CRP better has obvious improved（P 〈 0.05 or P 〈 0.01）, Naoluo Xintong particle group was significantly better than the Tong Xinluo group（P 〈 0.05）, detection of vascular conditioning and growth factors in ischemic stroke acute of deficiency of Qi and blood stasis in the role,that of Naoluo Xintong particle through effects on vascular and tempered and growth factor loss and improvement of ischemic stroke racute of Qi and blood stasis in patients with clinical symptoms. Conclusion： The CRP and o LAB levels were significantly lower in patients with ischemic stroke in acute stage of ischemic stroke.

关 键 词：脑梗死急性期 气虚血瘀证 临床研究 脑络欣通颗粒 

分 类 号：R271[医药卫生—中医妇科学]