盐酸舍曲林联合“三采嬉戏”疗法治疗原发性早泄的疗效观察  

Sertraline hydrochloride combined with four-spot caressing for primary premature ejaculation

作　　者：朱勇[1,2] 乐进[2] 刘正建[2] 黄健[3] 卞廷松[4] 王劲松[5] 曾庆琪[3,6] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210023 [2]南京中医药大学附属盐城市中医院男科,江苏盐城224001 [3]江苏省中医院男科,江苏南京210029 [4]南京中医药大学附属常州市中医医院男科,江苏常州213003 [5]徐州市第一人民医院男科,江苏徐州221002 [6]江苏建康职业学院中西医结合系,江苏南京210029

出　　处：《中华男科学杂志》2015年第12期1116-1120,共5页National Journal of Andrology

基　　金：江苏省“六大人才高峰”项目(WS-049)~~

摘　　要：目的:观察盐酸舍曲林联合"三采嬉戏"疗法治疗原发性早泄的临床疗效。方法:将90例原发性早泄患者随机均分为A组、B组和C组,年龄分别为(28.1±5.2)岁、(27.8±4.1)岁和(27.1±4.7)岁(P>0.05),病程分别为(3.1±1.9)年、(3.2±2.0)年和(3.1±2.0)年(P>0.05)。A组给予盐酸舍曲林50 mg,每天1次口服;B组每次性交时采用"三采嬉戏"疗法锻炼;C组联合使用A、B两种疗法。分别于治疗前、治疗后4周、8周和12周观察每组患者的射精潜伏期(IELT)和早泄评分(CIPE-5)。结果:3组患者IELT治疗前分别为(0.63±0.14)、(0.60±0.14)、(0.62±0.11)min,治疗4周后分别为(1.08±0.29)、(0.93±0.28)、(1.21±0.27)min,治疗8周后分别为(1.43±0.30)、(1.20±0.33)、(1.72±0.42)min,治疗12周后分别为(2.12±0.63)、(1.90±0.65)、(2.67±0.82)min。治疗后IELT均较治疗前明显改善(P<0.05);3组相互比较,C组改善程度更明显,优于其他两组(P<0.05)。3组患者CIPE-5评分治疗前分别为(12.57±2.05)、(13.20±2.51)、(13.07±2.01)min,治疗4周后分别为(15.17±1.74)、(14.57±1.94)、(15.60±1.63)min,治疗8周后分别为(17.13±1.63)、(16.37±1.97)、(18.00±1.05)min,治疗12周后分别为(18.93±1.57)、(18.53±1.67)、(20.00±1.46)min。治疗后各时间点CIPE-5评分均较治疗前明显改善(P<0.05);3组相互比较,C组改善程度更明显,优于其他两组(P<0.05)。结论:盐酸舍曲林联合"三采嬉戏"疗法疗效确切、不良反应小,对原发性早泄患者具有较高的推广和应用价值。Objective： To investigate the clinical effectiveness of sertraline hydrochloride combined with four-spot caress in the treatment of primary premature ejaculation（ PE）.Methods： We randomly assigned 90 primary PE patients to three groups of equal number.The patients in group A（ aged [28.1 ± 5.2] yr and with a disease course of [3.1 ± 1.9] yr） were treated with oral sertraline hydrochloride at 50 mg qd,those in B（ aged [27.8 ± 4.1]yr and with a disease course of [3.2 ± 2.0]yr） by four-spot caressing（ caressing the tongue,breasts,and vulva prior to intercourse）,and those in C（ aged [27.1 ± 4.7] yr and with a disease course of [3.1 ± 2.0]yr） by the combination of oral sertraline hydrochloride and four-spot caressing,all for 12 weeks.Before and after 4,8,and 12 weeks of treatment,we obtained the intravaginal ejaculatory latency time（ IELT） and Chinese Index of Sexual Function for Premature Ejaculation-5（ CIPE-5） scores and compared them among the three groups of patients.Results： The IELT was dramatically prolonged in groups A,B,and C after 4 weeks（ [1.08 ± 0.29],[0.93 ± 0.28] and [1.21 ± 0.27] min）,8 weeks（ [1.43 ±0.30],[1.20 ± 0.33] and [1.72 ± 0.42]min） and 12 weeks of treatment（ [2.12 ± 0.63],[1.90 ± 0.65]and [2.67 ± 0.82]min） as compared with the baseline（ [0.63 ± 0.14],[0.60 ± 0.14]and [0.62 ± 0.11]min）（ P〈0.05）,even longer in group C than in A and B（ P〈0.05）.The CIPE-5 scores were markedly improved in groups A,B and C after 4 weeks（ [15.17 ± 1.74 ],[14.57 ± 1.94]and [15.60 ± 1.63]min）,8 weeks（ [17.13 ± 1.63],[16.37 ± 1.97]and [18.00 ± 1.05]min） and 12 weeks of intervention（ [18.93 ± 1.57],[18.53 ± 1.67] and [20.00 ± 1.46] min） as compared with the baseline（ [12.57 ± 2.05 ],[13.20 ± 2.51]and[13.07 ± 2.01]min）（ P〈0.05）,even higher in group C than in A and B（ P〈0.05）.Conclusion： Sertraline hydrochloride combined with four-spot caressing,with its definite efficacy and rare adverse reactions,deser

关 键 词：原发性早泄 盐酸舍曲林 房中术疗法 阴道内射精潜伏期 中国早泄患者性功能评价表 

分 类 号：R698[医药卫生—泌尿科学]