厚朴总酚固体分散体不同制备方法的比较研究  

Comparison of total phenol of magnolia solid dispersion prepared by different methods

作　　者：李杰[1,2] 狄留庆[1,2] 李俊松[1,2] 康安[1,2] 钱静[1,2] 王灯节 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]江苏省中药高效给药系统工程技术研究中心,江苏南京210023

出　　处：《中国中药杂志》2015年第22期4400-4405,共6页China Journal of Chinese Materia Medica

基　　金：江苏省"333高层次人才培养工程"项目(BRA2013201);江苏高校优势学科建设工程项目(ysxk-2010)

摘　　要：比较研究厚朴总酚固体分散体不同制备方法之间的差异。分别使用热熔挤出法、溶剂蒸发法、熔融冷却法制备厚朴总酚Plastone S-630及HPC 2种辅料固体分散体。采用DSC,X-射线衍射评价所制备固体分散体中药物的分散状态;通过FTIR分析药物与辅料之间可能存在的连接方式;最后通过加速稳定性-溶出试验比较3种工艺的稳定性差异。DSC及X-射线衍射结果显示3种工艺制备的固体分散体中药物均能以无定形态存在;FT-IR结果也无法区别3种工艺间的差异;加速稳定性-溶出试验表明HPC所制备的固体分散体稳定性明显优于Plastone S-630,同种辅料间热熔挤出技术制备的固体分散体稳定性要好于其他2种工艺。To compare the difference of total phenol of magnolia solid dispersion prepared by different methods. Hot melt extrusion,solvent evaporation method,and fusion-cooling method were used to prepare total phenol of Magnolia accessory solid dispersion,Plastone S-630 and HPC. The drug dispersion state in the prepared solid dispersion was evaluated with DSC and X-ray diffraction; FT-IR method was used to analyze the possible connections between drug and accessories. Finally,accelerated stability-in vivo dissolution test was use to compare the stability differences between these three processes. The results of DSC and X-ray diffraction showed that all of the drug in solid dispersion processed by three processes can exist in amorphous form; FT-IR results also could not distinguish the difference between the three processes; accelerated stability-in vivo dissolution test showed the stability of solid dispersion prepared by HPC was better than Plastone S-630,and the same kinds of materials solid dispersion prepared by hot melt extrusion showed a better stability than the other two processes.

关 键 词：厚朴总酚 热熔挤出 溶剂蒸发 熔融冷却 工艺比较 

分 类 号：R283.6[医药卫生—中药学]