焦虑障碍的催产素-HPA轴异常及针刺干预机理探析  

Study of Mechanism of Acupuncture on the Abnormal of Oxytocin-HPA Axis in Anxiety Disorders

作　　者：魏京金 张承舜[1] 周奇志[1] 肖夏[1] 魏大能[1] 姚弘[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《成都中医药大学学报》2015年第4期102-105,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81173322);教育部博士点基金博导类课题(编号:20135132110009)

摘　　要：新近研究发现,催产素(Oxytocin,OT)系统的激活可抑制下丘脑-垂体-肾上腺轴(hypothalamo-pituitary-adrenalaxis,HPA轴)亢进而发挥抗焦虑效应;OT-HPA轴活性异常与焦虑障碍的发生密切相关。针刺对焦虑障碍有良好的调节作用。针刺调节焦虑障碍与OT-HPA轴是否相关,尚未见文献研究与分析报道。据此,本文拟从OT、HPA轴和OT-HPA轴与焦虑障碍,以及针刺调节OT-HPA轴这四方面,分析探讨针刺治疗焦虑障碍的OT-HPA轴调节机理,从而为针刺治疗焦虑障碍的新机制研究提供思路。Recent researches have been suggested that Oxytocin （OT） can be anxiolytic, while the hypothalamus-pituitary-ad- renal axis （ HPA axis） plays an essential role in anxiety disorderand OT attenuates anxiety behavior by inhibiting the functions of HPA axis. Acupuncture is known to be involved in the modulation of anxiety. However, it has not been reported that the relationships be- tween OT-HPA axis and acupuncture on anxiety disorders. In order to explore a possible mechanism of acupuncture on OT-HPA in anti- anxiety, we will discuss from the following four aspects that including the relationships between OT, HPA axis, OT-HPA axis and anxiety disorders for expand view on new mechanism of anti-anxiety with acupuncture.

关 键 词：针刺 催产素 HPA 焦虑障碍 

分 类 号：R245.3[医药卫生—针灸推拿学] R749.72[医药卫生—中医临床基础]