补中益气汤对胃癌术后气虚血瘀证胃肠功能恢复和营养状况的影响  

Influences of Buzhong Yiqi Tang on Gastrointestinal Function and Nutriture Status of Gastric Carcinoma After Operation

作　　者：刘凯[1] 王本军[2] 马恒[1] 宋希林[1] 卞瑞祺 

机构地区：[1]山东省肿瘤防治研究院,济南250117 [2]山东中医药大学附属医院,济南250014 [3]临沂市中医院,山东临沂276003

出　　处：《中国实验方剂学杂志》2015年第24期152-156,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山东省中医药科技发展计划项目(2013-210)

摘　　要：目的：观察补中益气汤加减对胃癌术后气虚血瘀证胃肠功能恢复以及对血清生长激素（GH）和营养状况的影响。方法：选择符合条件的胃癌手术后气虚血瘀证患者82例,参照数字表法随机分为研究组和对照组各41例;对照组于术后第2天至第9天给予肠内营养支持疗法;研究组在对照组治疗的基础上于术后2~9 d给予补中益气汤加减治疗;两组均连续治疗12周;记录两组术后首次排便、排气时间和肠鸣音恢复时间;比较两组术后腹胀发生率;检测两组GH,前白蛋白（PA）,白蛋白（ALB）和转铁蛋白（TRF）水平。结果：术后研究组患者的排便、排气和肠鸣音恢复时间均短于对照组（P〈0.01）;研究组临床优良率为53.66%,对照组为29.27%,研究组高于对照组,比较差异有统计学意义（P〈0.05）;术后24 h和48 h研究组患者腹胀发生率明显低于对照组,比较差异有统计学意义（P〈0.05,P〈0.01）;术后10 d,研究组患者血清GH,PA,ALB和TRF水平均明显高于对照组,比较差异均有统计学意义（P〈0.01）。结论：补中益气汤加减可促进胃癌术后胃肠功能恢复,提高GH水平,改善机体营养状况。Objective： To observe influences of Buzhong Yiqi Tang on gastrointestinal function,growth hormone（ GH） and nutriture status ofgastric carcinoma with qi-deficency and blood-stasis syndrome after operation. Method： Eighty two patients of gastric carcinoma with qi-deficency and blood-stasis syndrome were selected and randomly divided into control group and research group（ forty-one cases for each）. Patients of control group were treated with support therapy of enteral nutrition from day two to day nine after operation. Patients of treatment group were treated with Buzhong Yiqi Tang based on the control groupfrom day two to day nine after operation. Patients of two groups were treated for twelve weeks. After operation,time of defecation,evacuation and bowelsound for the first time in two groups were recorded. After operation,occurrence rates of abdominal distension were compared in two groups. Levels of GH, prealbumin（ PA）, albumin（ ALB） and transferrin（ TRF） were detected in two groups. Result： After operation,time of defecation,evacuation and bowelsound for the first time in research group were shorter than those of control one（ P 〈 0. 01）. The excellent and good rate of research group was 53. 66%, which was higher than that of control one of 29. 27% with statistical differences（ P 〈 0. 05）. Occurrence rates of abdominal distension in research group were evidently lower than those of control one 24,48 h after operation（ P 〈 0. 05,P 〈 0. 01）. Serum levels of GH,PA,ALB and TRF in research group were remarkably higher than control one ten days after operation with statistical differences（ P 〈 0. 01）.Conclusion： Buzhong Yiqi Tang could accelerate the recovery of gastrointestinal function,increase level of GH and improve nutriture status of gastric carcinoma after operation.

关 键 词：补中益气汤 胃癌 胃肠功能 营养状况 

分 类 号：R287.5[医药卫生—中药学]