化滞柔肝颗粒治疗湿热蕴结型非酒精性脂肪肝  

Huazhi Rougan Granule in Treating Damp-heat Accumulation Type Non-alcoholic Fatty Liver Disease

作　　者：杨书山[1] 郭洋[2] 李彤[2] 苏振武[1] 

机构地区：[1]衡水市哈励逊国际和平医院,河北衡水053000 [2]衡水市中医院,河北衡水053000

出　　处：《中国实验方剂学杂志》2015年第24期157-160,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：衡水市科技学术与发展计划项目(2014021A)

摘　　要：目的:观察化滞柔肝颗粒治疗非酒精性脂肪性肝病(NAFLD)湿热蕴结证的临床疗效以及对血清β抑制蛋白(β-arrestin)和骨钙素(OCN)的影响。方法:将180例NAFLD患者随机分为对照组和治疗组各90例。两组患者按照《非酒精性脂肪性肝病诊疗指南》给予非药物基础治疗;对照组给予复方蛋氨酸胆碱片口服,3片/次,3次/d;治疗组给予化滞柔肝颗粒内服,1袋/次,3次/d,每服6 d停服1 d。所有患者均给予12周治疗。检测两组丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST),总胆固醇(TC)和甘油三酯(TG)水平;观察两组中医证候评分、体质量指数(BMI)和腰围/臀围比(WHR);检测两组血清β抑制蛋白-1(β-arrestin-1),β抑制蛋白-2(β-arrestin-2)和骨钙素(OCN)水平。结果:治疗组临床总有效率为92.22%,对照组为77.77%,治疗组优于对照组(P<0.05);治疗组治疗后ALT,AST,TC和TG水平明显低于对照组(P<0.01);治疗组治疗后中医证候积分和BMI明显低于对照组,比较差异有统计学意义(P<0.01);治疗组治疗后β-arrestin-1明显低于对照组,OCN明显高于对照组,比较差异有统计学意义(P<0.01);两组治疗后血清β-arrestin-2含量均无明显变化。结论:化滞柔肝颗粒治疗NAFLD湿热蕴结证可改善临床证候,保护肝功能,促进血脂好转,降低患者血清β-arrestin-1和升高OCN水平。Objective： To observe the clinical efficacy of Huazhi Rougan granule in treating damp-heat accumulation type non-alcoholic fatty liver disease（ NAFLD） and its influence on serum β-arrestin and osteocalcin levels. Method： One hundred and eighty NAFLD patients were randomly divided into control group（ 90 cases）and treatment group（ 90 cases）. Both groups received basic treatment without drug referring to Clinical Practice Guideline for Non-alcoholic Fatty Liver Disease. Patients of control group also received compound methionine and choline bitartrate tablets（ 3 tablets / time,tid）. Patients in treatment group also received Huazhi Rougan granule（ 1 dose /d,tid,and resting for 1 d every 6 ds）. Course of treatment was 12 weeks for both groups. Alanine aminotransferase（ ALT）,aspartate transaminase（ AST）,total cholesterol（ TC）,and triglyceride（ TG） levels were detected between both groups. Symptom scores of traditional Chinese medicine（ TCM）,body mass index（ BMI）,and waist-hip ratio（ WHR） were observed between two groups. Serum β-arrestin-1,β-arrestin-2,and OCN levels were measured. Result： The total efficacy of treatment group was 92. 22%,higher than 77. 77% in control group,with statistical difference（ P 〈 0. 05）. Compared with control group,ALT,AST,TC,and TG levels in treatment group were significantly decreased after treatment（ P 〈 0. 01）. TCM scores and BMI of treatment group were significantly lower than those in control group after treatment,with statistically significant difference（ P 〈 0. 01）. After treatment,serum β-arrestin-1 level in treatment group was significantly lower than that in control group,and OCN was higher in treatment group,with statistical difference（ P 〈 0. 01）,howeverβ-arrestin-2 level for two groups was not obviously changed before and after treatment. Conclusion： Huazhi Rougan granule could improve clinical signs in treating damp-heat accumulation type NAFLD,protect liver function,promote blood lipid back t

关 键 词：非酒精性脂肪肝 化滞柔肝颗粒 湿热蕴结证 β抑制蛋白 骨钙素 

分 类 号：R287[医药卫生—中药学]