经胸超声心动图测量心外膜脂肪厚度与冠心病的相关性研究  

Relationship between epicardial adipose tissue thickness by transthoracic echocardiography and coronary heart disease

作　　者：彭红玉[1] 柳景华[1] 吕志阳[2] 郑旭伟[1] 章新新[3] 

机构地区：[1]首都医科大学附属北京安贞医院北京心肺血管病研究所心内科28病房,北京100029 [2]湖北宜昌市中心人民医院心内科三峡大学心血管病研究所 [3]首都医科大学附属北京安贞医院北京心肺血管病研究所超声诊断科

出　　处：《临床心血管病杂志》2015年第12期1279-1282,共4页Journal of Clinical Cardiology

基　　金：首都医科大学基础临床科研合作基金资助项目(No:12JL57)

摘　　要：目的：评价经胸超声心动图测量心外膜脂肪（EAT）厚度与冠心病的相关性和预测价值。方法：150例住院患者经冠状动脉（冠脉）造影分为冠心病组（100例）和非冠心病组（50例）。经胸超声心动图测量EAT厚度,并比较两组临床资料及EAT厚度的差异。利用Logistic回归模型和ROC曲线分析EAT厚度与冠心病的关系及诊断价值。结果：冠心病组EAT厚度中位数为4.78（3.75-6.47）mm,明显高于非冠心病组3.43（2.97-4.10）mm（P〈0.001）。Logistic回归分析显示,除了合并糖尿病、BMI≥25之外,EAT厚度（OR=3.966,95%CI：1.234-12.743,P=0.021）也是冠心病的一个独立危险因素。EAT厚度≥4.61 mm诊断冠心病的敏感性为58%,特异性为86%,ROC曲线下面积为0.766（95%CI：0.690-0.842,P〈0.001）。结论：经胸超声心动图测量的EAT厚度与冠心病发生密切相关,可作为冠心病筛查的一种有效的无创检查方法。Objective：To evaluate the relationship between echocardiographic epicardial adipose tissue（EAT）thickness and the presence of coronary heart disease（CHD）,and the value of EAT thickness for the diagnosis of CHD.Method：A total of 150 patients were divided into two groups according to the result of coronary angiography：CHD group with significant coronary stenosis（n=100） and non-CHD group without significant lesions（n=50）.EAT thickness on the free wall of the right ventricle was measured using echocardiography.EAT thickness were compared with angiographic results.Result;EAT thickness was significantly higher in CHD group than in non-CHD group（median：5.09 mm vs 3.36 mm,P〈0.001）.Multivariate analysis showed EAT thickness was an independent factor affecting CHD（OR：3.966,95%CI：1.234-12.743,P = 0.021）.EAT thickness of ≥4.61 mm had 58%sensitivity and 86%specificity for predicting CHD（ROC area：0.766,95%CI：0.690-0.842,P〈0.001）.Conclusion：The transthoracic echocardiography measurement of EAT thickness is correlated with the presence of angiographic CHD,and may provide valuable predictive information for CHD,

关 键 词：经胸超声心动图 冠心病 心外膜脂肪 

分 类 号：R541.4[医药卫生—心血管疾病]