N_2诱导低氧性大鼠肺动脉高压模型的建立  

N_2 induced hypoxic pulmonary hypertension model in rat

作　　者：杜明成[1] 夏世辉 秦廷江 王朝辉[1] 刘盈贝 姚凤芝[1] 安永[1] 

机构地区：[1]重庆医科大学附属儿童医院心胸外科儿童发育疾病研究教育部重点实验室认知发育与学习记忆障碍转化医学重庆市重点实验室,重庆400014

出　　处：《临床心血管病杂志》2015年第12期1350-1353,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金面上项目(No:NSFC81370432);国家临床重点专科建设项目资助(No:国卫办医函[2013]544)

摘　　要：肺动脉高压（pulmonary arterial hypertension,PAH）是一种进行性和致命性的疾病,其特征主要表现在肺动脉的收缩和血管的重构,随着疾病的发展,肺动脉血管管腔狭窄、血管阻力增加,以代偿增加的负荷和血管阻力,导致右心室结构和电生理重构,最终导致右心衰竭（心衰）和死亡。Fifty SD male rats were included into control group（n=10） and experimental group（n =40）.The rats in experimental group were pre-placed in the moderate hypoxia environment in one week,and finally were put in oxygen concentration of 8%-9% for 16 days.The body weight were measured once every other days,cardiac structures were detected by echocardiography,pulmonary artery and right ventricular pressure were monitored at 4 th,8 th,12 th,16 th day respectively,the ultrastructural of the pulmonary artery was measured by electron microscopy.

关 键 词：N2 肺动脉高压模型 大鼠 缺氧 

分 类 号：R331[医药卫生—人体生理学]