大蒜皮中肉桂酰胺N-trans-feruloyloctopamine对老年痴呆大鼠模型的治疗作用  

Effect of N-trans-feruloyloctopamine from Garlic Skin on Alzheimer's Disease Model Rats

作　　者：武燕[1] 刘健[2] 吴争荣[3] 

机构地区：[1]甘肃中医药大学,兰州730030 [2]兰州大学第一附属医院,兰州730030 [3]兰州大学药学院,兰州730030

出　　处：《中国现代应用药学》2015年第12期1437-1439,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：甘肃省科技计划项目(1506RJYA039)

摘　　要：目的研究大蒜皮中的肉桂酰胺类化合物N-trans-feruloyloctopamine(FO)对老年痴呆模型大鼠的治疗作用。方法采用Meynert基底核注射Aβ1-40建立老年痴呆大鼠模型,再给予FO进行灌胃后,测定大鼠脑内乙酰胆碱(Ach)、乙酰胆碱转移酶(Ch AT)及乙酰胆碱酯酶(Ach E)活性等指标,HE染色后观察大鼠海马区神经细胞形态变化。结果与模型组比较,酪氨酸酶抑制剂FO组的Ach,Ch AT和Ach E均具有显著性差异(P<0.05,P<0.01);病理结果显示FO对Aβ引起的大鼠海马皮层神经元变性坏死症状明显改善。结论 FO对大鼠AD模型具有较好防治作用。OBJECTIVE To investigate the effects of N-trans-feruloyloctopamine from garlic skin on Alzheimer＇s disease model rats. METHODS Adopted Aβ1-40 injected into meynert nuclei basales of rats to establish Alzheimer＇s disease model, then the compound was given by i.g. to the Alzheimer＇s disease model rats, the activities of acetylcholine, acetylcholine transferase and acetylcholinesterase of all samples were detected, the brain tissues were stained by HE staining, the ultrastructure images of the coronary slides in rat hippocampus were examined by electron microscope observation. RESULTS Compared with the model group, the related indexs had differences significantly in FO group（P〈0.05, P〈0.01）. Pathology showed FO could protect neuron apoptosis caused by toxicity of Aβ. CONCLUSION FO has the good function to prevent and treat Alzheimer＇s disease on model rats.

关 键 词：N-trans-feruloyloctopa MINE 大蒜皮 酪氨酸酶 老年痴呆 

分 类 号：R965.2[医药卫生—药理学]