氯沙坦对急性心力衰竭患者的疗效及超敏C反应蛋白和血清肌钙蛋白T的影响  

Curative effect of losartan on patients with acute heart failure and its influence on high-sensitivity C-reactive protein and serum cardiac troponin T

作　　者：李亚美[1] 丁春晖[1] 

机构地区：[1]江苏省泰兴市中医院内科,江苏泰兴225400

出　　处：《中国医药科学》2015年第20期40-42,45,共4页China Medicine And Pharmacy

摘　　要：目的探讨急性失代偿性心力衰竭患者应用氯沙坦的疗效及对超敏C反应蛋白（hs-CRP）和血清肌钙蛋白T（c Tn T））影响。方法选取我院2012年2月~2015年2月收治的急性失代偿性心力衰竭患者54例,随机分为对照组和实验组。实验组给予常规治疗以及氯沙坦治疗,而对照组仅给予常规治疗。比较两组治疗前后的心功能、超声心动图、血压指标、hs-CRP、c Tn T的变化,以及临床疗效。结果治疗后,两组的纽约心脏病学会（NYHA）心功能分级、左心室收缩末期内径（LVESD）、左心室射血分数（LVEF）、左心室舒张末期内径（LVEDD）以及舒张压（DBP）、收缩压（SBP）均较治疗前改善,两组间差异有统计学意义（P〈0.05）;治疗后,两组的超敏C反应蛋白（hs-CRP）和血清肌钙蛋白T（c Tn T）均较治疗前显著改善,且两组间差异有统计学意义（P〈0.05）。且实验组治疗总有效率为96.42%,对照组为73.08%,两组间差异有统计学意义（P〈0.05）。结论对于急性失代偿性心力衰竭患者的治疗,在常规治疗基础上再给予氯沙坦能够改善心功能、血压情况,这可能与氯沙坦能够降低患者机体hs-CRP及c Tn T水平有着密切关系,临床效果显著,值得临床推广应用。Objective To explore curative effect of losartan in treatment of patients with acute decompensated heart failure and its influence on high-sensitivity C-reactive protein（hs-CRP）and serum cardiac troponin T（c Tn T）. Methods 54 patients with acute decompensate heart failure who were admitted to our hospital from February 2012 to February 2015 were randomly allocated to the control group and the experiment group. The experimental groupwas given conventional treatment and losartan treatment while the control group was only given conventional treatment.Cardiac function,echocardiography,blood pressure index,hs-CRP,c Tn T and clinical curative effect before and after treatment of two groups were compared. Results Cardiac functional grading,left ventricular end systolic diameter（LVESD）,left ventricular ejection fraction（LVEF）,left ventricular end-diastolic diameter（LVEDD）,diastolic blood pressure（DBP）and systolic blood pressure（SBP）of New York heart association（NYHA）after treatment of two groups were all improved than those before treatment.Differences between the two groups were statistically significant（P〈0.05）.After treatment,hs-CRP,c Tn T of two groups were both significantly improved than those before treatment.Differences between the two groups were statistically significant（P〈0.05）.Total effective rate of the experimental group was 96.42% while the total effective rate of the control group was 73.08%.Differences between the two groups were statistically significant（P〈0.05）. Conclusion Losartan at basis of conventional treatment in treatment of patientswith acute decompensated heart failure can improve cardiac function and blood pressure.This improvement may relate to that Losartan can reduce the hs-CRP and c Tn T levels of patients.The clinical curative effect is remarkable so it is worthy of clinical promotion and application.

关 键 词：氯沙坦 急性失代偿性心力衰竭 超敏C反应蛋白 血清肌钙蛋白T 

分 类 号：R541.6[医药卫生—心血管疾病]